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Hematology Reports
Volume 6
Issue 1
10.4081/hr.2014.4996
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Article

Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies

by
Fabrizio Vianello
1,*,
Silvia Vettore
1,
Fabiana Tezza
1,
Luca De Toni
2,
Raffaella Scandellari
1,
Luisa Sambado
1,
Martina Treleani
1 and
Fabrizio Fabris
1
1
Internal Medicine Unit, Department of Medicine, University of Padova, Via Giustiniani 1, 35128 Padova, Italy
2
Centre for Human Reproduction Pathology, Department of Medicine DIMED, University of Padova Medical School, 35128 Padova, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2014, 6(1), 4996; https://doi.org/10.4081/hr.2014.4996
Submission received: 19 July 2013 / Revised: 21 January 2014 / Accepted: 10 February 2014 / Published: 26 March 2014

Abstract

The relationship between thrombopoietin (TPO) and its receptor cMpl in thrombocytopenic conditions has not been entirely clarified. To elucidate this interplay may expand the spectrum of indications of TPO mimetics. In this study we have explored the relationship between TPO and cMpl in platelets and megakaryocytes of 43 patients with thrombocytopenia due to idiopathic thrombocytopenic purpura (ITP), bone marrow hypoplasia, myelodysplastic syndromes (MDS), and familial thrombocytopenia. Data were compared to cMpl and TPO in patients with a normal platelet count and in patients with thrombocytosis due to essential thrombocythemia (ET). All but familial patients showed higher TPO compared to controls. All thrombocytopenic states were invariably associated with increased expression of platelet cMPL compared to healthy controls. ET patients showed normal TPO and a trend toward a reduced cMpl expression. Immunofluorescence of bone marrow sections from patients with ITP and MDS failed to show a peculiar pattern compared to controls. Multiple mechanisms regulate TPO and cMpl in thrombocytopenic conditions.
Keywords: thrombocytopenia; thrombopoietin; thrombopoietin receptor; thrombopoiesis thrombocytopenia; thrombopoietin; thrombopoietin receptor; thrombopoiesis

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MDPI and ACS Style

Vianello, F.; Vettore, S.; Tezza, F.; Toni, L.D.; Scandellari, R.; Sambado, L.; Treleani, M.; Fabris, F. Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies. Hematol. Rep. 2014, 6, 4996. https://doi.org/10.4081/hr.2014.4996

AMA Style

Vianello F, Vettore S, Tezza F, Toni LD, Scandellari R, Sambado L, Treleani M, Fabris F. Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies. Hematology Reports. 2014; 6(1):4996. https://doi.org/10.4081/hr.2014.4996

Chicago/Turabian Style

Vianello, Fabrizio, Silvia Vettore, Fabiana Tezza, Luca De Toni, Raffaella Scandellari, Luisa Sambado, Martina Treleani, and Fabrizio Fabris. 2014. "Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies" Hematology Reports 6, no. 1: 4996. https://doi.org/10.4081/hr.2014.4996

APA Style

Vianello, F., Vettore, S., Tezza, F., Toni, L. D., Scandellari, R., Sambado, L., Treleani, M., & Fabris, F. (2014). Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies. Hematology Reports, 6(1), 4996. https://doi.org/10.4081/hr.2014.4996

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