Next Article in Journal
Concurrent Remission of Therapy-Related Acute Myeloid Leukemia and IgG-λ MGUS During Oral Decitabine–Cedazuridine: A Case Report
Previous Article in Journal
Ophelia-like Paraneoplastic Limbic Encephalitis with Haemorrhagic Temporal Lobe Involvement and Cauda Equina Dysfunction in Classical Hodgkin Lymphoma: A Case Report
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Hematology Reports
Volume 18
Issue 5
10.3390/hematolrep18050065
hematolrep-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Steatotic Liver Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Case Series and Literature Review

by
Karthik Chetlapalli
1,*,
Clifford Shin
2,
Stuart Seropian
1,
Francine Foss
1,
Iris Isufi
1,
Sarah Perreault
1,
Manoj Pillai
1,
Amer Zeidan
1,
Mahan Mathur
2,
Noffar Bar
1,
Charles Kenworthy
1,
Gary Israel
2 and
Lohith Gowda
1
1
Section of Hematology, Department of Medicine, Yale School of Medicine, New Haven, CT 06510, USA
2
Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT 06510, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2026, 18(5), 65; https://doi.org/10.3390/hematolrep18050065
Submission received: 4 May 2026 / Revised: 26 June 2026 / Accepted: 10 July 2026 / Published: 10 September 2026
Versions Notes

Abstract

Background/Objectives: Obesity and inflammatory conditions, including steatotic liver disease, are known to impact the hematopoietic niche and immune surveillance. Therefore, assessing the impact of steatotic liver disease on recipients of allogeneic stem cell transplantation (allo-HSCT) with bone marrow origin neoplasms is clinically relevant and an underexplored area of investigation. Methods: We followed the clinical course of allo-HSCT recipient patients with steatotic liver. Results: From 2014 to 2020 at our center, we identified 18 patients (5.8% of 306 patients screened) with steatotic liver disease detected on non-contrast CT imaging pre-transplant. With a minimum of 5 years follow-up for all, eight patients experienced post-transplant relapses (44%). Relapses (78%) followed by infections (55%) were the major contributors of mortality in this cohort. Pre-transplant transaminases were normal (AST median 28, ALT median 37) in all, while most patients (89%; 16/18) developed abnormal transaminases in the first-year post-transplantation without evidence of permanent liver injury. None experienced veno-occlusive disease of the liver. The cumulative incidence of acute graft-versus-host disease (aGVHD) was 33% (6/18), with 55% (10/18) experiencing chronic graft-versus-host disease (cGVHD). Conclusions: Our descriptive study highlights that radiologically detected steatotic liver disease is not a contraindication to proceeding with allogeneic stem cell transplant, and its association with transaminitis, relapse, immune complications, and post-transplant metabolic health requires future mechanistic studies.
Keywords: steatotic liver disease; MASLD; hematopoetic stem cell transplantation; hematological malignancy; graft-versus-host-disease steatotic liver disease; MASLD; hematopoetic stem cell transplantation; hematological malignancy; graft-versus-host-disease

Share and Cite

MDPI and ACS Style

Chetlapalli, K.; Shin, C.; Seropian, S.; Foss, F.; Isufi, I.; Perreault, S.; Pillai, M.; Zeidan, A.; Mathur, M.; Bar, N.; et al. Steatotic Liver Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Case Series and Literature Review. Hematol. Rep. 2026, 18, 65. https://doi.org/10.3390/hematolrep18050065

AMA Style

Chetlapalli K, Shin C, Seropian S, Foss F, Isufi I, Perreault S, Pillai M, Zeidan A, Mathur M, Bar N, et al. Steatotic Liver Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Case Series and Literature Review. Hematology Reports. 2026; 18(5):65. https://doi.org/10.3390/hematolrep18050065

Chicago/Turabian Style

Chetlapalli, Karthik, Clifford Shin, Stuart Seropian, Francine Foss, Iris Isufi, Sarah Perreault, Manoj Pillai, Amer Zeidan, Mahan Mathur, Noffar Bar, and et al. 2026. "Steatotic Liver Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Case Series and Literature Review" Hematology Reports 18, no. 5: 65. https://doi.org/10.3390/hematolrep18050065

APA Style

Chetlapalli, K., Shin, C., Seropian, S., Foss, F., Isufi, I., Perreault, S., Pillai, M., Zeidan, A., Mathur, M., Bar, N., Kenworthy, C., Israel, G., & Gowda, L. (2026). Steatotic Liver Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Case Series and Literature Review. Hematology Reports, 18(5), 65. https://doi.org/10.3390/hematolrep18050065

Article Metrics

Back to TopTop