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Hematology Reports
Volume 12
Issue 3
10.4081/hr.2020.8380
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Brief Report

Comparison of Post-Remission Strategies in Acute Myeloid Leukemia: Autologous Hematopoietic Stem Cell Transplantation versus Consolidation Chemotherapy

by
Zeynep Arzu Yegin
*,
Asena Dikyar
,
Lale Aydın Kaynar
,
Ferda Can
,
Zübeyde Nur Özkurt
and
Münci Yağcı
Department of Hematology, Gazi University School of Medicine, Beşevler, Ankara 06680, Turkey
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2020, 12(3), 8380; https://doi.org/10.4081/hr.2020.8380
Submission received: 15 November 2019 / Revised: 1 July 2020 / Accepted: 10 July 2020 / Published: 2 December 2020

Abstract

Autologous Hematopoietic Stem Cell Transplantation (auto-HSCT) has become a therapeutic option for first-line consolidation in Acute Myeloid Leukemia (AML) patients with favorable and intermediate risk features. A total of 101 AML patients in first complete remission, who were not eligible for allogeneic HSCT, were randomized to receive intensive cytarabine-based chemotherapy or to undergo auto-HSCT. The probability of LFS was significantly better in auto-HSCT recipients compared to chemotherapy arm (43% vs. 4.8%, p = 0.008). At the end of 915 (30–4470) days of followup, the probability of overall survival was better in auto-HSCT group compared to chemotherapy, without statistical significance (79.2% vs. 38.8%, p = 0.054). Multivariate analysis revealed a significant predictive impact of cytogenetic risk status on OS (p = 0.002, HR: 2.824, 95% CI: 1.445–5.521). Auto-HSCT is considered as an effective consolidation approach in favorable and intermadiate risk AML patients.
Keywords: acute myeloid leukemia; autologous hematopoietic stem cell transplantation; consolidation chemotherapy; leukemia relapse; prognosis acute myeloid leukemia; autologous hematopoietic stem cell transplantation; consolidation chemotherapy; leukemia relapse; prognosis

Share and Cite

MDPI and ACS Style

Yegin, Z.A.; Dikyar, A.; Kaynar, L.A.; Can, F.; Özkurt, Z.N.; Yağcı, M. Comparison of Post-Remission Strategies in Acute Myeloid Leukemia: Autologous Hematopoietic Stem Cell Transplantation versus Consolidation Chemotherapy. Hematol. Rep. 2020, 12, 8380. https://doi.org/10.4081/hr.2020.8380

AMA Style

Yegin ZA, Dikyar A, Kaynar LA, Can F, Özkurt ZN, Yağcı M. Comparison of Post-Remission Strategies in Acute Myeloid Leukemia: Autologous Hematopoietic Stem Cell Transplantation versus Consolidation Chemotherapy. Hematology Reports. 2020; 12(3):8380. https://doi.org/10.4081/hr.2020.8380

Chicago/Turabian Style

Yegin, Zeynep Arzu, Asena Dikyar, Lale Aydın Kaynar, Ferda Can, Zübeyde Nur Özkurt, and Münci Yağcı. 2020. "Comparison of Post-Remission Strategies in Acute Myeloid Leukemia: Autologous Hematopoietic Stem Cell Transplantation versus Consolidation Chemotherapy" Hematology Reports 12, no. 3: 8380. https://doi.org/10.4081/hr.2020.8380

APA Style

Yegin, Z. A., Dikyar, A., Kaynar, L. A., Can, F., Özkurt, Z. N., & Yağcı, M. (2020). Comparison of Post-Remission Strategies in Acute Myeloid Leukemia: Autologous Hematopoietic Stem Cell Transplantation versus Consolidation Chemotherapy. Hematology Reports, 12(3), 8380. https://doi.org/10.4081/hr.2020.8380

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