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Hematology Reports
Volume 11
Issue 3
10.4081/hr.2019.7971
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

A Variant of Acute Promyelocytic Leukemia with t(4;17)(q12;q21) Showed Two Different Clinical Symptoms

by
Takahisa Nakanishi
1,
Aya Nakaya
1,*,
Yusuke Nishio
2,
Shinya Fujita
1,
Atsushi Satake
1,
Yoshiko Azuma
1,
Yukie Tsubokura
1,
Ryo Saito
1,
Akiko Konishi
1,
Masaaki Hotta
1,
Hideaki Yoshimura
1,
Yoshihiko Kadosaka
2,
Kazuyoshi Ishii
1,
Tomoki Ito
1,
Koji Tsuta
2 and
Shosaku Nomura
1
1
First Department of Internal Medicine, Kansai Medical University, 2-5-1, Shin-machi, Hirakata, Osaka 573-1010, Japan
2
Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka 573-1010, Japan
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2019, 11(3), 7971; https://doi.org/10.4081/hr.2019.7971
Submission received: 14 December 2018 / Revised: 21 June 2019 / Accepted: 5 July 2019 / Published: 18 September 2019

Abstract

A 63-year-old man was diagnosed with a rare variant of acute promyelocytic leukemia (APL) with t(4;17)(q12; q21) that showed atypical morphological features and two different clinical symptoms. He was started on standard induction chemotherapy for acute myeloid leukemia, which decreased myeloblast numbers; however, APL-like blasts remained. He then received a salvage therapy that added all-trans retinoic acid (ATRA). After ATRA commenced, APL-like blasts disappeared and cytogenetic analysis became normal. However, myeloblasts subsequently increased, and he became resistant. In summary, this patient exhibited two different clinical courses of acute myeloid leukemia and APL.
Keywords: acute promyelocytic leukemia; t(4;17)(q12;q21); PML-RARA; all-trans retinoic acid acute promyelocytic leukemia; t(4;17)(q12;q21); PML-RARA; all-trans retinoic acid

Share and Cite

MDPI and ACS Style

Nakanishi, T.; Nakaya, A.; Nishio, Y.; Fujita, S.; Satake, A.; Azuma, Y.; Tsubokura, Y.; Saito, R.; Konishi, A.; Hotta, M.; et al. A Variant of Acute Promyelocytic Leukemia with t(4;17)(q12;q21) Showed Two Different Clinical Symptoms. Hematol. Rep. 2019, 11, 7971. https://doi.org/10.4081/hr.2019.7971

AMA Style

Nakanishi T, Nakaya A, Nishio Y, Fujita S, Satake A, Azuma Y, Tsubokura Y, Saito R, Konishi A, Hotta M, et al. A Variant of Acute Promyelocytic Leukemia with t(4;17)(q12;q21) Showed Two Different Clinical Symptoms. Hematology Reports. 2019; 11(3):7971. https://doi.org/10.4081/hr.2019.7971

Chicago/Turabian Style

Nakanishi, Takahisa, Aya Nakaya, Yusuke Nishio, Shinya Fujita, Atsushi Satake, Yoshiko Azuma, Yukie Tsubokura, Ryo Saito, Akiko Konishi, Masaaki Hotta, and et al. 2019. "A Variant of Acute Promyelocytic Leukemia with t(4;17)(q12;q21) Showed Two Different Clinical Symptoms" Hematology Reports 11, no. 3: 7971. https://doi.org/10.4081/hr.2019.7971

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