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Hematology Reports
Volume 11
Issue 3
10.4081/hr.2019.7964
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Osteopontin Expression and Its Relationship with Prognostic Factors in Diffuse Large B-Cell Lymphoma

by
Gilberto Barranco
1,
Edith Fernández
2,3,
Silvia Rivas
4,
Roxana Quezada
5,
Dolores Nava
5,
José Aguilar
6,
Abelardo García
2,
Horacio Astudillo
7,
Carmen Lome
5 and
Erika Ruiz
2,*
1
Department of Hematology, General Hospital of Mexico, Mexico City 06720, Mexico
2
Translational Medicine, National Institute of Cancerology, Mexico City 14080, Mexico
3
Computational Genomics, National Institute of Genomic Medicine, Mexico City 14610, Mexico
4
Department of Hematology, National Institute of Cancerology, Mexico City 14080, Mexico
5
Department of Pathology, National Institute of Cancerology, Mexico City 14080, Mexico
6
Department of Internal Medicine, National Institute of Cancerology, Mexico City 14080, Mexico
7
Laboratory of Translational Cancer Research and Cellular Therapy, National Medical Center Siglo XXI, San Fernando No.22. Col Belisario Dominguez Secc 16, Delegación Tlalpan, Mexico City 14080, Mexico
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2019, 11(3), 7964; https://doi.org/10.4081/hr.2019.7964
Submission received: 5 December 2018 / Revised: 4 June 2019 / Accepted: 5 July 2019 / Published: 18 September 2019

Abstract

The aim of this study is to explore the expression of osteopontin (OPN) and its relationship with prognostic factors and survival in diffuse large B cell lymphoma (DLBCL). A tissue microarray was performed for immunohistochemical evaluation. Contingency tables were analyzed for trends; chi-square test was used to determine differences between groups. Univariate and multivariate Cox proportional hazards-regression analyses were performed to evaluate the impact of prognostic factors on survival. Expression of OPN was observed in 28%. It was different in non-germinal center DLBCL (p = 0.04). The mean overall survival (OS) was lower in patients with positive OPN expression (19.762; CI 95% 14.269–25.255) it was not significant (p = 0.123). It is not possible to establish a clear relationship between the expression by immunohistochemistry of osteopontin and a poor prognosis but it would be important to complement the analysis with other techniques as PCR or NGS that allow us to assess the influence of the isoforms and post-translational modifications of OPN on the biological behavior of DLBCL. Our findings indicate that OPN expression could be associated with a more aggressive variant of lymphoma: non-germinal center DLBCL.
Keywords: osteopontin; lymphoma; prognosis osteopontin; lymphoma; prognosis

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MDPI and ACS Style

Barranco, G.; Fernández, E.; Rivas, S.; Quezada, R.; Nava, D.; Aguilar, J.; García, A.; Astudillo, H.; Lome, C.; Ruiz, E. Osteopontin Expression and Its Relationship with Prognostic Factors in Diffuse Large B-Cell Lymphoma. Hematol. Rep. 2019, 11, 7964. https://doi.org/10.4081/hr.2019.7964

AMA Style

Barranco G, Fernández E, Rivas S, Quezada R, Nava D, Aguilar J, García A, Astudillo H, Lome C, Ruiz E. Osteopontin Expression and Its Relationship with Prognostic Factors in Diffuse Large B-Cell Lymphoma. Hematology Reports. 2019; 11(3):7964. https://doi.org/10.4081/hr.2019.7964

Chicago/Turabian Style

Barranco, Gilberto, Edith Fernández, Silvia Rivas, Roxana Quezada, Dolores Nava, José Aguilar, Abelardo García, Horacio Astudillo, Carmen Lome, and Erika Ruiz. 2019. "Osteopontin Expression and Its Relationship with Prognostic Factors in Diffuse Large B-Cell Lymphoma" Hematology Reports 11, no. 3: 7964. https://doi.org/10.4081/hr.2019.7964

APA Style

Barranco, G., Fernández, E., Rivas, S., Quezada, R., Nava, D., Aguilar, J., García, A., Astudillo, H., Lome, C., & Ruiz, E. (2019). Osteopontin Expression and Its Relationship with Prognostic Factors in Diffuse Large B-Cell Lymphoma. Hematology Reports, 11(3), 7964. https://doi.org/10.4081/hr.2019.7964

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