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Article

Studying Anemia of Chronic Disease and Iron Deficiency in Patients with Rheumatoid Arthritis by Iron Status and Circulating Hepcidin

1
Al-Shatra General Hospital, Al-Shatra, Dhi Qar, Iraq
2
Department of Pathology, College of Medicine, University of Baghdad, Baghdad 00964, Iraq
3
Department of Medicine, College of Medicine, University of Baghdad, Baghdad 00964, Iraq
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2019, 11(1), 7708; https://doi.org/10.4081/hr.2019.7708
Submission received: 11 April 2018 / Revised: 6 February 2019 / Accepted: 13 February 2019 / Published: 12 March 2019

Abstract

Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most important types of anemia in rheumatoid arthritis (RA). Functional iron deficiency in ACD can be attributed to overexpression of the main iron regulatory hormone hepcidin leading to diversion of iron from the circulation into storage sites resulting in iron-restricted erythropoiesis. The aim is to investigate the role of circulating hepcidin and to uncover the frequency of IDA in RA. The study included 51 patients with RA. Complete blood counts, serum iron, total iron binding capacity, ferritin, and hepcidin- 25 were assessed. ACD was found in 37.3% of patients, IDA in 11.8%, and combined (ACD/IDA) in 17.6%. Serum hepcidin was higher in ACD than in control and the other groups (P ≤ 0.001). It was strongly and positively correlated with ferritin (P < 0.001), while hemoglobin, serum iron, and total iron binding capacity were negatively correlated with hepcidin (P = 0.016, 0.022 and <0.001, respectively). High serum hepcidin was significantly associated with ACD in RA. IDA alone or combined with ACD was encountered in about a third of patients.
Keywords: rheumatoid arthiritis; anemia; hepcidin; ferritin rheumatoid arthiritis; anemia; hepcidin; ferritin

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MDPI and ACS Style

Khalaf, W.; Al-Rubaie, H.A.; Shihab, S. Studying Anemia of Chronic Disease and Iron Deficiency in Patients with Rheumatoid Arthritis by Iron Status and Circulating Hepcidin. Hematol. Rep. 2019, 11, 7708. https://doi.org/10.4081/hr.2019.7708

AMA Style

Khalaf W, Al-Rubaie HA, Shihab S. Studying Anemia of Chronic Disease and Iron Deficiency in Patients with Rheumatoid Arthritis by Iron Status and Circulating Hepcidin. Hematology Reports. 2019; 11(1):7708. https://doi.org/10.4081/hr.2019.7708

Chicago/Turabian Style

Khalaf, Warqaa, Haithem Ahmed Al-Rubaie, and Sami Shihab. 2019. "Studying Anemia of Chronic Disease and Iron Deficiency in Patients with Rheumatoid Arthritis by Iron Status and Circulating Hepcidin" Hematology Reports 11, no. 1: 7708. https://doi.org/10.4081/hr.2019.7708

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