Next Article in Journal
Chromosome Positioning in Interphase Nuclei of Hematopoietic Stem Cell and Myeloid Precursor
Previous Article in Journal
Neurofibromatosis Type I and Multiple Myeloma Coexistence: A Possible Link?
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Hematology Reports
Volume 10
Issue 1
10.4081/hr.2018.7070
hematolrep-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Extranodal Diffuse Large B-Cell Lymphomas: A Retrospective Case Series and Review of the Literature

by
Stergios Boussios
1,2,
Ioannis Zerdes
1,2,
Amalia Vassou
2,3,
Eleni Bareta
1,2,
Esmeralda Seraj
1,2,
Alexandra Papoudou-Bai
4,
Nicholas Pavlidis
1,2,
Anna Batistatou
4 and
George Pentheroudakis
1,2,*
1
Department of Medical Oncology, Medical School, University of Ioannina, Stavros Niarchou Avenue, 45110 Ioannina, Greece
2
Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), 45110 Ioannina, Greece
3
Department of Hematology, Medical School, University of Ioannina, 45110 Ioannina, Greece
4
Department of Pathology, Medical School, University of Ioannina, 45110 Ioannina, Greece
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2018, 10(1), 7070; https://doi.org/10.4081/hr.2018.7070
Submission received: 28 January 2017 / Revised: 15 April 2017 / Accepted: 18 April 2017 / Published: 3 April 2018

Abstract

Non-Hodgkin lymphomas commonly show extranodal involvement (25–30%) but primary diffuse large B-cell lymphomas (DLBCL) with extranodal localization represent clinically and molecularly distinct entities. The present study involved retrospective analysis of case records of 4 patients who were diagnosed with extranodal DLBCL between 2010 and 2016 at the Medical Oncology and Hematology Departments of the Ioannina University Hospital, Greece. Median age of presentation was 69 years (range 60–77 years). There were 2 males and 2 females. The sites of DLBCL involvement included adrenal gland, mandible, cervix uteri, and ileum. Two patients had B symptoms while none had bone marrow involvement. After staging workup, all the patients fell into IE stage. The treatment approach included chemotherapy combined with rituximab (R), whereas one patient received additionally irradiation therapy. Post-treatment positron emission tomography-computed tomography scan was performed in 3 patients. In terms of the outcome, 3 patients are alive in complete response, whereas one was lost in follow-up. Further prospective data analyses are required so as to better elucidate the biology and course of extranodal DLBCL.
Keywords: chemotherapy; extranodal; lymphomas; immunohistochemistry chemotherapy; extranodal; lymphomas; immunohistochemistry

Share and Cite

MDPI and ACS Style

Boussios, S.; Zerdes, I.; Vassou, A.; Bareta, E.; Seraj, E.; Papoudou-Bai, A.; Pavlidis, N.; Batistatou, A.; Pentheroudakis, G. Extranodal Diffuse Large B-Cell Lymphomas: A Retrospective Case Series and Review of the Literature. Hematol. Rep. 2018, 10, 7070. https://doi.org/10.4081/hr.2018.7070

AMA Style

Boussios S, Zerdes I, Vassou A, Bareta E, Seraj E, Papoudou-Bai A, Pavlidis N, Batistatou A, Pentheroudakis G. Extranodal Diffuse Large B-Cell Lymphomas: A Retrospective Case Series and Review of the Literature. Hematology Reports. 2018; 10(1):7070. https://doi.org/10.4081/hr.2018.7070

Chicago/Turabian Style

Boussios, Stergios, Ioannis Zerdes, Amalia Vassou, Eleni Bareta, Esmeralda Seraj, Alexandra Papoudou-Bai, Nicholas Pavlidis, Anna Batistatou, and George Pentheroudakis. 2018. "Extranodal Diffuse Large B-Cell Lymphomas: A Retrospective Case Series and Review of the Literature" Hematology Reports 10, no. 1: 7070. https://doi.org/10.4081/hr.2018.7070

APA Style

Boussios, S., Zerdes, I., Vassou, A., Bareta, E., Seraj, E., Papoudou-Bai, A., Pavlidis, N., Batistatou, A., & Pentheroudakis, G. (2018). Extranodal Diffuse Large B-Cell Lymphomas: A Retrospective Case Series and Review of the Literature. Hematology Reports, 10(1), 7070. https://doi.org/10.4081/hr.2018.7070

Article Metrics

Back to TopTop