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Volume 3
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10.4081/pr.2011.s2.e12
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Article

HLA-Mismatched Hematopoietic Stem Cell Tranplantation for Pediatric Solid Tumors

by
Andrea Pession
*,
Riccardo Masetti
,
Corinne Di Leo
,
Monica Franzoni
and
Arcangelo Prete
Pediatric Oncology and Hematology Lalla Seràgnoli Unit, University of Bologna, Bologna, Italy
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2011, 3(s2), e12; https://doi.org/10.4081/pr.2011.s2.e12
Submission received: 4 May 2011 / Accepted: 4 June 2011 / Published: 17 June 2011
Versions Notes

Abstract

Even if the overall survival of children with cancer is significantly improved over these decades, the cure rate of high-risk pediatric solid tumors such as neuroblastoma, Ewing’s sarcoma family tumors or rhabdomiosarcoma remain challenging. Autologous hematopoietic stem cell transplantation (HSCT) allows chemotherapy dose intensification beyond marrow tolerance and has become a fundamental tool in the multimodal therapeutical approach of these patients. Anyway this procedure does not allow to these children an eventfree survival approaching more than 50% at 5 years. New concepts of allogeneic HSCT and in particular HLA-mismatched HSCT for high risk solid tumors do not rely on escalation of chemo therapy intensity and tumor load reduction but rather on a graft-versus-tumor effect. We here report an experimental study design of HLA-mismatched HSCT for the treatment of pediatric solid tumors and the inherent preliminary results.
Keywords: HLA-mismatched hematopoietic stem cell tranplantation; childhood; solid tumors HLA-mismatched hematopoietic stem cell tranplantation; childhood; solid tumors

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MDPI and ACS Style

Pession, A.; Masetti, R.; Di Leo, C.; Franzoni, M.; Prete, A. HLA-Mismatched Hematopoietic Stem Cell Tranplantation for Pediatric Solid Tumors. Pediatr. Rep. 2011, 3, e12. https://doi.org/10.4081/pr.2011.s2.e12

AMA Style

Pession A, Masetti R, Di Leo C, Franzoni M, Prete A. HLA-Mismatched Hematopoietic Stem Cell Tranplantation for Pediatric Solid Tumors. Pediatric Reports. 2011; 3(s2):e12. https://doi.org/10.4081/pr.2011.s2.e12

Chicago/Turabian Style

Pession, Andrea, Riccardo Masetti, Corinne Di Leo, Monica Franzoni, and Arcangelo Prete. 2011. "HLA-Mismatched Hematopoietic Stem Cell Tranplantation for Pediatric Solid Tumors" Pediatric Reports 3, no. s2: e12. https://doi.org/10.4081/pr.2011.s2.e12

APA Style

Pession, A., Masetti, R., Di Leo, C., Franzoni, M., & Prete, A. (2011). HLA-Mismatched Hematopoietic Stem Cell Tranplantation for Pediatric Solid Tumors. Pediatric Reports, 3(s2), e12. https://doi.org/10.4081/pr.2011.s2.e12

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