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Pediatric Reports
Volume 12
Issue 1
10.4081/pr.2020.8382
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Pediatric Reports is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Renal Involvement at Diagnosis of Pediatric Acute Lymphoblastic Leukemia

by
Mayerly Prada-Rico
1,
Carmen Inés Rodríguez-Cuellar
2,*,
Lucy Natalia Arteaga Aya
3,
Claudia Lorena Nuñez Chates
4,
Sandra Patricia Garces Sterling
5,
Mathieu Pierotty
6,
Luz Esthella Gonzalez Chaparro
1 and
Ricardo Gastelbondo Amaya
1
1
Pediatric Nephrology Division, Pediatrics Deparment, Fundación Cardioinfantil, Bogotá
2
Pediatric Nephrology Division, Pediatrics Department, Clínica Shaio, Bogotá
3
Pediatric Deparment, Universidad el Bosque, Bogotá
4
Pediatric Deparment, Universidad del Rosario, Bogotá
5
Pediatric Hematology Oncology Division, Pediatrics Department, Fundación Cardioinfantil, Bogotá
6
Radiology and Medical Diagnostic Images, Fundación Cardioinfantil, Bogotá
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2020, 12(1), 8382; https://doi.org/10.4081/pr.2020.8382
Submission received: 18 November 2019 / Revised: 6 December 2019 / Accepted: 10 December 2019 / Published: 8 April 2020

Abstract

Acute leukemia is the most common type of cancer in pediatric patients. This type of cancer accounts for a third of all childhood cancer cases. More than half of pediatric acute leukemia patients show signs and symptoms such as hepatomegaly, splenomegaly, pallor, fever and bruising at the time of diagnosis. In early stages of acute lymphoblastic leukemia (ALL), nephromegaly and other renal manifestations such as high blood pressure (HBP) and renal failure are uncommon, although renal infiltration and nephromegaly are common in advanced-stage pediatric patients. This is a retrospective case review with a critical appraisal of the existing evidence from the literature. We present a clinical case of a child with HBP associated with bilateral nephromegaly which resolved after chemotherapy treatment. This patient presented with HBP that required pharmacological treatment, likely owing to nephromegaly. All HBP secondary causes were rejected. Nephromegaly was resolved after chemotherapy treatment, and antihypertensive medication was discontinued. Nephromegaly and HBP are rare manifestations of ALL debut in pediatrics. The present case report illustrates this unusual combination and Suggests clinicians to consider malignancy as its causal factor, especially if the symptoms are accompanied by other suggestive extrarenal manifestations.
Keywords: nephromegaly; hypertension; acute lymphoblastic leukemia nephromegaly; hypertension; acute lymphoblastic leukemia

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MDPI and ACS Style

Prada-Rico, M.; Rodríguez-Cuellar, C.I.; Arteaga Aya, L.N.; Nuñez Chates, C.L.; Garces Sterling, S.P.; Pierotty, M.; Gonzalez Chaparro, L.E.; Gastelbondo Amaya, R. Renal Involvement at Diagnosis of Pediatric Acute Lymphoblastic Leukemia. Pediatr. Rep. 2020, 12, 8382. https://doi.org/10.4081/pr.2020.8382

AMA Style

Prada-Rico M, Rodríguez-Cuellar CI, Arteaga Aya LN, Nuñez Chates CL, Garces Sterling SP, Pierotty M, Gonzalez Chaparro LE, Gastelbondo Amaya R. Renal Involvement at Diagnosis of Pediatric Acute Lymphoblastic Leukemia. Pediatric Reports. 2020; 12(1):8382. https://doi.org/10.4081/pr.2020.8382

Chicago/Turabian Style

Prada-Rico, Mayerly, Carmen Inés Rodríguez-Cuellar, Lucy Natalia Arteaga Aya, Claudia Lorena Nuñez Chates, Sandra Patricia Garces Sterling, Mathieu Pierotty, Luz Esthella Gonzalez Chaparro, and Ricardo Gastelbondo Amaya. 2020. "Renal Involvement at Diagnosis of Pediatric Acute Lymphoblastic Leukemia" Pediatric Reports 12, no. 1: 8382. https://doi.org/10.4081/pr.2020.8382

APA Style

Prada-Rico, M., Rodríguez-Cuellar, C. I., Arteaga Aya, L. N., Nuñez Chates, C. L., Garces Sterling, S. P., Pierotty, M., Gonzalez Chaparro, L. E., & Gastelbondo Amaya, R. (2020). Renal Involvement at Diagnosis of Pediatric Acute Lymphoblastic Leukemia. Pediatric Reports, 12(1), 8382. https://doi.org/10.4081/pr.2020.8382

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