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Infectious Disease Reports
Volume 4
Issue 1
10.4081/idr.2012.e6
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Infectious Disease Reports is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Brief Report

False Negative HIV Antibody Test in HIV Infected Children Who Receive Early Antiretroviral Treatment in a Resource-Limited Setting

by
Gerardo Alvarez-Uria
1,*,
Praveen K. Naik
1,
Manoranjan Midde
1,
Shanmugamari Kannan
1 and
Raghuprakash Reddy
2
1
Department of Infectious Diseases, Rural Development Trust Hospital, Bathalapalli, Anantapur district, AP, India
2
Department of Microbiology, Rural Development Trust Hospital, Bathalapalli, Anantapur district, AP, India
*
Author to whom correspondence should be addressed.
Infect. Dis. Rep. 2012, 4(1), e6; https://doi.org/10.4081/idr.2012.e6
Submission received: 20 October 2011 / Revised: 19 December 2011 / Accepted: 23 December 2011 / Published: 4 January 2012

Abstract

With the implementation of 2010 World Health Organization guidelines, the number of infants from developing countries who will initiate antiretroviral therapy (ART) will increase considerably. In this study we describe the HIV antibody tests of 14 HIV infected children who initiated ART at age less than one year in a rural setting of India. The HIV rapid test was negative in seven and indeterminate in two cases, whereas the HIV enzyme-linked immunosorbent assay (ELISA) antibody test was negative in three and indeterminate in one case. In one child who had both negative HIV rapid test and ELISA initially, HIV serology turned positive after having a virological failure to ART, suggesting the possibility of utilizing HIV serology for monitoring ART effectiveness in children who experience HIV seroreversion. In conclusion, HIV seroreversion of children with early initiation of ART is common and should be considered for avoiding misdiagnosis of HIV infection.
Keywords: HIV; Pediatrics; Diagnosis; Serology HIV; Pediatrics; Diagnosis; Serology

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MDPI and ACS Style

Alvarez-Uria, G.; Naik, P.K.; Midde, M.; Kannan, S.; Reddy, R. False Negative HIV Antibody Test in HIV Infected Children Who Receive Early Antiretroviral Treatment in a Resource-Limited Setting. Infect. Dis. Rep. 2012, 4, e6. https://doi.org/10.4081/idr.2012.e6

AMA Style

Alvarez-Uria G, Naik PK, Midde M, Kannan S, Reddy R. False Negative HIV Antibody Test in HIV Infected Children Who Receive Early Antiretroviral Treatment in a Resource-Limited Setting. Infectious Disease Reports. 2012; 4(1):e6. https://doi.org/10.4081/idr.2012.e6

Chicago/Turabian Style

Alvarez-Uria, Gerardo, Praveen K. Naik, Manoranjan Midde, Shanmugamari Kannan, and Raghuprakash Reddy. 2012. "False Negative HIV Antibody Test in HIV Infected Children Who Receive Early Antiretroviral Treatment in a Resource-Limited Setting" Infectious Disease Reports 4, no. 1: e6. https://doi.org/10.4081/idr.2012.e6

APA Style

Alvarez-Uria, G., Naik, P. K., Midde, M., Kannan, S., & Reddy, R. (2012). False Negative HIV Antibody Test in HIV Infected Children Who Receive Early Antiretroviral Treatment in a Resource-Limited Setting. Infectious Disease Reports, 4(1), e6. https://doi.org/10.4081/idr.2012.e6

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