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Gastroenterology Insights
Volume 4
Issue 1
10.4081/gi.2012.e9
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Gastroenterology Insights is published by MDPI from Volume 11 Issue 1 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Oral High Dose Beclomethasone Dipropionate for Treatment of Active Ulcerative Colitis

by
Simona Di Caro
1,2,*,
Dario Raimondo
3,
Benedetto Mangiavillano
4,
Enzo Masci
4,
Alberto Mariani
5,
Antonio Gasbarrini
6,
Antonino De Lorenzo
2,
Laura Di Renzo
2 and
Ennio La Rocca
3
1
Department of Gastroenterology, University College Hospital, London, UK
2
Division of Human Nutrition, University of Tor Vergata, Rome, Italy
3
Gastroenterology and Digestive Endoscopy, San Raffaele-Giglio Hospital, Cefalù, Italy
4
Gastroenterology and Digestive Endoscopy, San Paolo Hospital, Milan, Italy
5
Department of Gastroenterology and Digestive Endoscopy, San Raffaele Hospital, IRCCS, Milan, Italy
6
Department of Internal Medicine, Catholic University, Rome, Italy
*
Author to whom correspondence should be addressed.
Gastroenterol. Insights 2012, 4(1), e9; https://doi.org/10.4081/gi.2012.e9
Submission received: 6 August 2011 / Revised: 5 March 2012 / Accepted: 20 March 2012 / Published: 16 May 2012

Abstract

Oral corticosteroids (CS) have been widely used for treatment of ulcerative colitis (UC) at the price of systemic side effects. Role of topically active oral beclomethasone dipropionate (BDP) in clinical practice is still unclear. The aim of this paper is to investigate efficacy and tolerability of a high dose BDP regimen in mild to moderately active UC. Twenty-five patients (9 males, aged 25-40 years) with mild to moderately active UC, unresponsive to oral and topical 5-ASA (4.8 gr daily) and BDP (5 mg daily), were enrolled. All patients continued 5-ASA plus high dose oral BDP (15 mg od for 4 weeks and than tapered). Clinical, endoscopic, histological and laboratory parameters were monitored. Mean disease activity index (DAI) score at study entry was 8.82±4. Response to treatment was observed in all patients after 2 weeks. Remission was observed in all patients within 4-6 weeks from entering the study (mean DAI score: 2.34±0.5) and maintained throughout 6-month follow-up. No major adverse events were documented. Quality of life global evaluation score improved. This study provides the first evidence of efficacy and safety of high dose oral BDP-scheme in UC demonstrating excellent tolerability and favourable acceptability profile. This new BDPscheme might be a valid alternative to conventional oral CS when standard dose BDP is not effective. Future studies are needed to explore further clinical indications.
Keywords: oral beclomtethasone dipropionate; ulcerative colitis; treatment; quality of life oral beclomtethasone dipropionate; ulcerative colitis; treatment; quality of life

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MDPI and ACS Style

Di Caro, S.; Raimondo, D.; Mangiavillano, B.; Masci, E.; Mariani, A.; Gasbarrini, A.; De Lorenzo, A.; Di Renzo, L.; La Rocca, E. Oral High Dose Beclomethasone Dipropionate for Treatment of Active Ulcerative Colitis. Gastroenterol. Insights 2012, 4, e9. https://doi.org/10.4081/gi.2012.e9

AMA Style

Di Caro S, Raimondo D, Mangiavillano B, Masci E, Mariani A, Gasbarrini A, De Lorenzo A, Di Renzo L, La Rocca E. Oral High Dose Beclomethasone Dipropionate for Treatment of Active Ulcerative Colitis. Gastroenterology Insights. 2012; 4(1):e9. https://doi.org/10.4081/gi.2012.e9

Chicago/Turabian Style

Di Caro, Simona, Dario Raimondo, Benedetto Mangiavillano, Enzo Masci, Alberto Mariani, Antonio Gasbarrini, Antonino De Lorenzo, Laura Di Renzo, and Ennio La Rocca. 2012. "Oral High Dose Beclomethasone Dipropionate for Treatment of Active Ulcerative Colitis" Gastroenterology Insights 4, no. 1: e9. https://doi.org/10.4081/gi.2012.e9

APA Style

Di Caro, S., Raimondo, D., Mangiavillano, B., Masci, E., Mariani, A., Gasbarrini, A., De Lorenzo, A., Di Renzo, L., & La Rocca, E. (2012). Oral High Dose Beclomethasone Dipropionate for Treatment of Active Ulcerative Colitis. Gastroenterology Insights, 4(1), e9. https://doi.org/10.4081/gi.2012.e9

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