Next Article in Journal
Prevalence of Helicobacter pylori Infection in Dyspeptic Patients in Iran
Previous Article in Journal
Oral High Dose Beclomethasone Dipropionate for Treatment of Active Ulcerative Colitis
Gastroenterology Insights is published by MDPI from Volume 11 Issue 1 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on as a courtesy and upon agreement with PAGEPress.
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:

A Clinicopathological Study of Dyspeptic Subjects in Lagos, Nigeria

Ladi Hameed
Charles Asabamaka Onyekwere
Jesse Abiodun Otegbayo
3 and
Fatimah B. Abdulkareem
L Hoffman La Roche, Nigeria
Department of Medicine, Lagos State University Teaching Hospital, Nigeria
Department of Medicine, University College Hospital, Ibadan, Nigeria
Department of Morbid Anatomy, Lagos University Teaching Hospital, Nigeria
Author to whom correspondence should be addressed.
Gastroenterol. Insights 2012, 4(1), e11;
Submission received: 28 May 2011 / Revised: 22 August 2011 / Accepted: 22 February 2012 / Published: 28 May 2012


The clinicopathological and endoscopic features of dyspepsia have not been well studied in Nigeria due to the high cost of gastroscopes and lack of the relevant expertise. This study was designed to highlight these features and possible risk factors. This prospective study was conducted on adult dyspeptic patients who fulfilled the study criteria from November 2007 to December 2008 at a University hospital in Lagos, Nigeria. Demographic and clinical presentation including possible risk factors were obtained through a questionnaire administered by an interviewer followed by an upper gastrointestinal endoscopy and gastric biopsy. Of the 123 subjects who took part in the study, 100 gave their consent to an upper gastrointestinal endoscopy and biopsy. The male:female ratio was 1:1, mean age was 44.98 (SD 15.4) years and the modal age group was 38-47years. The prevalence of dyspepsia was 29% and epigastric pain was the most common presentation. Endoscopic findings were superficial mucosal lesion (21%), peptic ulcer (16%), features of gastroesophageal reflux disease (10%), and gastric cancer (2%), as well normal findings (44%). Non-steroidal antiinflammatory drug (NSAID) use as a risk factor had a significant association with positive endoscopic findings; relative risk for development of positive endoscopic findings was 1.5% (P =0.03). Histology showed rates of chronic gastritis to be 91% and normal values 9%. The most common type of gastritis was the non-specific form (59.3%), followed by H. Pylori-associated gastritis (36.3%). The topography of gastritis was mainly pangastritis (68.1%) and antral predominant in 23.1%. The prevalence of H. pylori by histology was 41%. The presence of H. pylori was not associated with severity, location or duration of symptoms. H. pylori was, however, found to be a significant contributor to the development of positive endoscopic findings (P=0.01; OR 2.92 95% CI 1.50-3.17). Alarm symptoms were found to be important markers of malignancy. Dyspeptic illness is common,with peak incidence in the 4th decade of life and no gender predilection. Epigastric pain has the most discriminatory value with alarm symptoms in cases of gastric cancer. Risk factors such as NSAID use and H. pylori infection had a very significant impact on endoscopic findings while presence of H. pylori, smoking and alcohol consumption were associated with increased risk of developing chronic gastritis.
Keywords: dyspepsia; risk factors dyspepsia; risk factors

Share and Cite

MDPI and ACS Style

Hameed, L.; Onyekwere, C.A.; Otegbayo, J.A.; Abdulkareem, F.B. A Clinicopathological Study of Dyspeptic Subjects in Lagos, Nigeria. Gastroenterol. Insights 2012, 4, e11.

AMA Style

Hameed L, Onyekwere CA, Otegbayo JA, Abdulkareem FB. A Clinicopathological Study of Dyspeptic Subjects in Lagos, Nigeria. Gastroenterology Insights. 2012; 4(1):e11.

Chicago/Turabian Style

Hameed, Ladi, Charles Asabamaka Onyekwere, Jesse Abiodun Otegbayo, and Fatimah B. Abdulkareem. 2012. "A Clinicopathological Study of Dyspeptic Subjects in Lagos, Nigeria" Gastroenterology Insights 4, no. 1: e11.

Article Metrics

Back to TopTop