Impact of Endoscopic Band Ligation on Gastric Complications Associated with Portal Hypertension
Abstract
1. Introduction
2. Materials and Methods
Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
CSPH | Clinically Significant Portal Hypertension |
EGD | Esophagogastroduodenoscopy |
GOV2 | Type 2 Gastroesophageal Varices |
JRSH | Japanese Research Society for Portal Hypertension |
OR | Odds Ratios |
PH | Portal Hypertension |
PHG | Portal Hypertension Gastropathy |
PHPs | Portal Hypertension Polyps |
References
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Patients (N = 44) | |
---|---|
Demographic and anthropometric data | |
Age (years) | 64 ± 12 |
Male gender, n (%) | 36 (82) |
BMI (Kg/m2) | 24 ± 5 |
Disease characteristics | |
Disease duration (years) | 4 ± 5 |
CHILD–PUGH | |
A, n (%) | 18 (41) |
B, n (%) | 20 (45) |
C, n (%) | 6 (14) |
CHILD–PUGH, numeric | 7 ± 2 |
Disease etiology | |
Viral, n (%) | 9 (21) |
Alcoholic, n (%) | 19 (43) |
Metabolic, n (%) | 16 (36) |
Hepatic encephalopathy, n (%) | 44 (100%) |
Ascites, n (%) | 18 (41) |
Hepatocarcinoma, n (%) | 8 (18) |
Score | |
APRI | 1 ± 2 |
FIB-4 | 10 ± 8 |
Dysmetabolic comorbidities, n (%) | |
T2DM | 15 (34) |
Hypertension | 18 (41) |
Treatments | |
Emergency ligature, n (%) | 16 (36) |
Election ligature, n(%) | 28 (64) |
Beta blockers, n (%) | 22 (50) |
With PHG (n.26) | Without PHG (n.18) | p-Value | |
---|---|---|---|
Demographic and anthropometric | |||
Age (years) | 64 ± 11 | 62 ± 14 | 0.517 |
Male gender, n (%) | 23 (89) | 13 (72) | 0.170 |
BMI (Kg/m2) | 24 ± 5 | 24 ± 5 | 0.893 |
Disease characteristics | |||
Disease duration (years) | 4 ± 4 | 4 ± 7 | 0.674 |
CHILD–PUGH, numeric | 8 ± 2 | 7 ± 2 | 0.065 |
Disease etiology | 0.124 | ||
Viral, n (%) | 8 (31) | 1 (5) | 0.124 |
Alcoholic, n (%) | 10 (38) | 9 (50) | 0.124 |
Metabolic, n (%) | 8 (31) | 8 (44) | 0.124 |
Hepatic encephalopathy, n (%) | 26 (100) | 18 (100) | |
Ascites, n (%) | 14 (54) | 4 (22) | 0.036 |
Hepatocarcinoma, n (%) | 5 (19) | 3 (17) | 0.828 |
Dysmetabolic comorbidities | |||
T2DM | 8 (31) | 7 (39) | 0.576 |
Hypertension | 9 (35) | 9 (50) | 0.307 |
Biohumoral parameters | |||
Hb (g/dL) | 9 ± 2 | 8 ± 2 | 0.139 |
PLT (109/µL) | 71 ± 46 | 88 ± 66 | 0.268 |
INR | 1 ± 0 | 1 ± 0 | 0.726 |
Albumin (g/dL) | 3 ± 0 | 3 ± 0 | 0.317 |
Creatinine (mg/dL) | 1 ± 0 | 1 ± 0 | 0.277 |
GGT (U/L) | 206 ± 396 | 125 ± 107 | 0.407 |
ALT (UI/L) | 68 ± 148 | 37 ± 26 | 0.381 |
AST (UI/L) | 100 ± 163 | 53 ± 52 | 0.252 |
Bilirubin (g/dL) | 3 ± 2 | 2 ± 1 | 0.072 |
Score | |||
FIB-4 | 11 ± 8 | 8 ± 9 | 0.170 |
APRI SCORE | 1 ± 2 | 1 ± 1 | 1.412 |
Treatments | |||
Emergency ligature, n (%) | 15 (58) | 13 (72) | 0.325 |
Election ligature, n(%) | 11 (42) | 5 (28) | 0.325 |
Beta blockers, n (%) | 16 (61) | 6 (33) | 0.066 |
PHG Not Worsened (n.16) | PHG Worsened (n.28) | OR (95% CI) | p-Value | |
---|---|---|---|---|
Demographic and anthropometric data | ||||
Age (years) | 66 ± 9 | 62 ± 13 | 1 (0.9–1.0) | 0.294 |
Male gender, n (%) | 13 (81) | 23 (82) | 0.9 (0.2–4.6) | 0.941 |
BMI (Kg/m2) | 24 ± 5 | 24 ± 5 | 1 (0.9–1.1) | 0.707 |
Disease characteristics | ||||
Disease duration (years) | 4 ± 3 | 4 ± 6 | 1.0 (0.9–1.1) | 0.637 |
CHILD–PUGH numeric | 8 ± 2 | 7 ± 2 | 0.8 (0.5–1.1) | 0.171 |
Disease etiology | ||||
Viral, n (%) | 5 (31) | 4 (14) | 1.6 (0.7–3.7) | 0.283 |
Alcoholic, n (%) | 6 (37) | 13 (46) | 1.6 (0.7–3.7) | 0.283 |
Metabolic, n (%) | 5 (31) | 11 (39) | 1.6 (0.7–3.7) | 0.283 |
Hepatic encephalopathy, n (%) | 16 (100) | 28 (100) | ||
Ascites, n (%) | 10 (62) | 8 (28) | 4.2 (1.1–15.3) | 0.032 |
Hepatocarcinoma, n (%) | 3 (19) | 5 (18) | 1.0 (0.2–5.1) | 0.941 |
Gastric varices T0, n (%) | 0 (0) | 3 | 0 | 0.999 |
PHPs T0, n (%) | 1 (6) | 1 | 1.8 (0.1–31) | 0.695 |
Dysmetabolic comorbidities | ||||
T2DM | 4 (25) | 11 (39) | 0.5 (0.1–2.0) | 0.340 |
Hypertension | 6 (37) | 12 (43) | 1.2 (0.3–4.4) | 0.728 |
Biohumoral parameters | ||||
Hb (g/dL) | 9 ± 3 | 8 ± 2 | 0.835 (0.6–1.1) | 0.167 |
PLT (109/µL) | 79 ± 44 | 77 ± 50 | 1.0 (0.98–1.02) | 0.876 |
INR | 1 ± 0 | 1 ± 0 | 2.2 (0.2–25.9) | 0.524 |
Albumin (g/dL) | 3 ± 0 | 3 ± 0 | 1.2 (0.4–3.7) | 0.741 |
Creatinine (mg/dL) | 1.2 ± 1 | 0.8 ± 0 | 0.4 (0.1–1.2) | 0.107 |
GGT (U/L) | 221 ± 493 | 145 ± 134 | 0.99 (0.99–1.0) | 0.467 |
ALT (UI/L) | 88 ± 185 | 36 ± 32 | 0.99 (0.98–1.0) | 0.280 |
AST (UI/L) | 120 ± 1202 | 58 ± 55 | 0.97 (0.9–1.0) | 0.191 |
Bilirubin (g/dL) | 2 ± 2 | 2 ± 2 | 0.95 (0.7–1.3) | 0.761 |
Score | ||||
FIB-4 | 11 ± 8 | 9 ± 8 | 0.97 (0.9–1) | 0.432 |
APRI SCORE | 2 ± 3 | 1 ± 1 | 0.9 (0.6–1.2) | 0.362 |
Treatment | ||||
Emergency ligature, n (%) | 8 (50) | 20 (72) | 0.4 (0.1–1.4) | 0.160 |
Election ligature, n (%) | 8 (50) | 8 (28) | 0.4 (0.1–1.4) | 0.160 |
Beta blockers, n (%) | 11 (69) | 11 (39) | 3.4 (0.9–12.5) | 0.050 |
Treatment | Pros | Cons |
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NSBBs |
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EBL |
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Gambardella, M.L.; Fabiano, G.; Spagnuolo, R.; De Marco, R.; Luppino, I.; Franco, G.; Rettura, F.; Verta, M.; Luzza, F.; Abenavoli, L. Impact of Endoscopic Band Ligation on Gastric Complications Associated with Portal Hypertension. Gastroenterol. Insights 2025, 16, 28. https://doi.org/10.3390/gastroent16030028
Gambardella ML, Fabiano G, Spagnuolo R, De Marco R, Luppino I, Franco G, Rettura F, Verta M, Luzza F, Abenavoli L. Impact of Endoscopic Band Ligation on Gastric Complications Associated with Portal Hypertension. Gastroenterology Insights. 2025; 16(3):28. https://doi.org/10.3390/gastroent16030028
Chicago/Turabian StyleGambardella, Maria Luisa, Giulia Fabiano, Rocco Spagnuolo, Rosanna De Marco, Ileana Luppino, Giusi Franco, Francesco Rettura, Mario Verta, Francesco Luzza, and Ludovico Abenavoli. 2025. "Impact of Endoscopic Band Ligation on Gastric Complications Associated with Portal Hypertension" Gastroenterology Insights 16, no. 3: 28. https://doi.org/10.3390/gastroent16030028
APA StyleGambardella, M. L., Fabiano, G., Spagnuolo, R., De Marco, R., Luppino, I., Franco, G., Rettura, F., Verta, M., Luzza, F., & Abenavoli, L. (2025). Impact of Endoscopic Band Ligation on Gastric Complications Associated with Portal Hypertension. Gastroenterology Insights, 16(3), 28. https://doi.org/10.3390/gastroent16030028