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Neurology International
Volume 5
Issue 3
10.4081/ni.2013.e14
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Amino Acid Sequences Mediating Vascular Cell Adhesion Molecule 1 Binding to Integrin Alpha 4: Homologous DSP Sequence Found for JC Polyoma VP1 Coat Protein

by
Michael Andrew Meyer
Department of Neurology, Tennova Health Care, Knoxville, TN, USA
Neurol. Int. 2013, 5(3), e14; https://doi.org/10.4081/ni.2013.e14
Submission received: 5 May 2013 / Revised: 5 May 2013 / Accepted: 10 July 2013 / Published: 22 July 2013

Abstract

The JC polyoma viral coat protein VP1 was analyzed for amino acid sequences homologies to the IDSP sequence which mediates binding of VLA-4 (integrin alpha 4) to vascular cell adhesion molecule 1. Although the full sequence was not found, a DSP sequence was located near the critical arginine residue linked to infectivity of the virus and binding to sialic acid containing molecules such as integrins (3). For the JC polyoma virus, a DSP sequence was found at residues 70, 71 and 72 with homology also noted for the mouse polyoma virus and SV40 virus. Three dimensional modeling of the VP1 molecule suggests that the DSP loop has an accessible site for interaction from the external side of the assembled viral capsid pentamer.
Keywords: JC; polyoma; virus; VP1; capsid; alpha 4 integrin; PML JC; polyoma; virus; VP1; capsid; alpha 4 integrin; PML

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MDPI and ACS Style

Meyer, M.A. Amino Acid Sequences Mediating Vascular Cell Adhesion Molecule 1 Binding to Integrin Alpha 4: Homologous DSP Sequence Found for JC Polyoma VP1 Coat Protein. Neurol. Int. 2013, 5, e14. https://doi.org/10.4081/ni.2013.e14

AMA Style

Meyer MA. Amino Acid Sequences Mediating Vascular Cell Adhesion Molecule 1 Binding to Integrin Alpha 4: Homologous DSP Sequence Found for JC Polyoma VP1 Coat Protein. Neurology International. 2013; 5(3):e14. https://doi.org/10.4081/ni.2013.e14

Chicago/Turabian Style

Meyer, Michael Andrew. 2013. "Amino Acid Sequences Mediating Vascular Cell Adhesion Molecule 1 Binding to Integrin Alpha 4: Homologous DSP Sequence Found for JC Polyoma VP1 Coat Protein" Neurology International 5, no. 3: e14. https://doi.org/10.4081/ni.2013.e14

APA Style

Meyer, M. A. (2013). Amino Acid Sequences Mediating Vascular Cell Adhesion Molecule 1 Binding to Integrin Alpha 4: Homologous DSP Sequence Found for JC Polyoma VP1 Coat Protein. Neurology International, 5(3), e14. https://doi.org/10.4081/ni.2013.e14

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