Next Article in Journal
Malignant Ependymoblastoma Mimicking a Benign Pilocytic Astrocytoma
Previous Article in Journal
Publisher’s Note: Continued Publication of Neurology International by MDPI
Article

The Role of Apparent Diffusion Coefficient in the Differentiation between Cerebellar Medulloblastoma and Brainstem Glioma

by 1,† and 1,2,3,*,†
1
Department of Radiology, Hanoi Medical University, Ha Noi 100000, Vietnam
2
Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 700000, Vietnam
3
Department of Radiology, Children’s Hospital 02, Ho Chi Minh City 700000, Vietnam
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Neurol. Int. 2020, 12(3), 34-40; https://doi.org/10.3390/neurolint12030009
Received: 1 September 2020 / Accepted: 23 October 2020 / Published: 29 October 2020
For certain clinical circumstances, the differentiation between cerebellar medulloblastoma and brainstem glioma is essential. We aimed to evaluate the role played by the apparent diffusion coefficient (ADC) values in the differentiation between cerebellar medulloblastomas and brainstem gliomas in children. The institutional review board approved this prospective study. Brain magnetic resonance imaging (MRI), including diffusion-weighted imaging (DWI) and ADC, was assessed in 32 patients (median age: 7.0 years), divided into two groups, a medulloblastoma group (group 1, n = 22) and a brainstem glioma group (group 2, n = 10). The Mann–Whitney U test was utilized to compare tumor ADCmax, ADCmin, ADCmean, and ADCsd values, and their ratios with the parenchyma values between the two groups. Receiver operating characteristic (ROC) curve analysis and the Youden index were used to calculate the cut-off value, along with the area under the curve (AUC), sensitivity, and specificity. The median ADCmax, ADCmin, and ADCmean values were significantly higher in group 2 than in group 1 (p < 0.05). The median ratios of ADCmin and ADCmean to the parenchyma were significantly higher in group 2 than in group 1 (p < 0.05). The ROC analysis showed that the AUC for the ADCmean ratio was the highest among these parameters, at 98.2%. The ADCmean tumor to parenchyma ratio was a significant and effective parameter for the differentiation between pediatric medulloblastomas and brainstem gliomas. View Full-Text
Keywords: cerebellar medulloblastoma; brainstem glioma; magnetic resonance imaging; apparent diffusion coefficient cerebellar medulloblastoma; brainstem glioma; magnetic resonance imaging; apparent diffusion coefficient
Show Figures

Figure 1

MDPI and ACS Style

Minh Thong, P.; Minh Duc, N. The Role of Apparent Diffusion Coefficient in the Differentiation between Cerebellar Medulloblastoma and Brainstem Glioma. Neurol. Int. 2020, 12, 34-40. https://doi.org/10.3390/neurolint12030009

AMA Style

Minh Thong P, Minh Duc N. The Role of Apparent Diffusion Coefficient in the Differentiation between Cerebellar Medulloblastoma and Brainstem Glioma. Neurology International. 2020; 12(3):34-40. https://doi.org/10.3390/neurolint12030009

Chicago/Turabian Style

Minh Thong, Pham, and Nguyen Minh Duc. 2020. "The Role of Apparent Diffusion Coefficient in the Differentiation between Cerebellar Medulloblastoma and Brainstem Glioma" Neurology International 12, no. 3: 34-40. https://doi.org/10.3390/neurolint12030009

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop