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Biventricular Strain Imaging with Cardiac MRI in Genotyped and Histology Validated Amyloid Cardiomyopathy
Review

Cardiac Amyloidosis: Diagnostic Tools for a Challenging Disease

Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy
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Academic Editor: Juan Ramon Gimeno
Cardiogenetics 2021, 11(3), 111-121; https://doi.org/10.3390/cardiogenetics11030012
Received: 7 January 2021 / Revised: 23 June 2021 / Accepted: 27 June 2021 / Published: 23 July 2021
Amyloidosis is a group of diseases in which amyloid fibrils build up in tissues, leading to organ dysfunction. Cardiac involvement is observed in immunoglobulin light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR) and, when it occurs, the prognosis worsens. Cardiac tissue infiltration can lead to restrictive cardiomyopathy with clinical signs of diastolic heart failure, without reduction of ejection fraction (HFpEF). The aim of multiple and less invasive diagnostic tests is to discern peculiar characteristics and reach the diagnosis without performing an invasive endomyocardial biopsy. These diagnostic tools allow early diagnosis, and they are crucial to best benefit from target therapy. In this review article, we describe the mechanism behind amyloid fibril formation, infiltration of tissues, and consequent clinical signs, focusing on the diagnostic tools and the red flags to obtain a diagnosis. View Full-Text
Keywords: cardiac amyloidosis; amyloidosis diagnosis cardiac amyloidosis; amyloidosis diagnosis
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MDPI and ACS Style

Migliaccio, M.G.; Iodice, F.; Di Mauro, M.; Iannuzzi, A.; Pacileo, R.; Caiazza, M.; Esposito, A. Cardiac Amyloidosis: Diagnostic Tools for a Challenging Disease. Cardiogenetics 2021, 11, 111-121. https://doi.org/10.3390/cardiogenetics11030012

AMA Style

Migliaccio MG, Iodice F, Di Mauro M, Iannuzzi A, Pacileo R, Caiazza M, Esposito A. Cardiac Amyloidosis: Diagnostic Tools for a Challenging Disease. Cardiogenetics. 2021; 11(3):111-121. https://doi.org/10.3390/cardiogenetics11030012

Chicago/Turabian Style

Migliaccio, Marco G., Franco Iodice, Marco Di Mauro, Angela Iannuzzi, Roberta Pacileo, Martina Caiazza, and Augusto Esposito. 2021. "Cardiac Amyloidosis: Diagnostic Tools for a Challenging Disease" Cardiogenetics 11, no. 3: 111-121. https://doi.org/10.3390/cardiogenetics11030012

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