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Pharmaceutics
Volume 15
Issue 3
10.3390/pharmaceutics15030819
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Article

Composite PLGA–Nanobioceramic Coating on Moxifloxacin-Loaded Akermanite 3D Porous Scaffolds for Bone Tissue Regeneration

by
Georgia K. Pouroutzidou
1,2,*,
Lambrini Papadopoulou
3,
Maria Lazaridou
4,
Konstantinos Tsachouridis
5,
Chrysanthi Papoulia
1,
Dimitra Patsiaoura
1,
Ioannis Tsamesidis
2,
Konstantinos Chrissafis
1,
George Vourlias
1,
Konstantinos M. Paraskevopoulos
1,
Antonios D. Anastasiou
5,
Dimitrios N. Bikiaris
4 and
Eleana Kontonasaki
2,*
1
Advanced Materials and Devices Laboratory, Faculty of Sciences, School of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
2
Department of Prosthodontics, Faculty of Health Sciences, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
3
School of Geology, Faculty of Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
4
Faculty of Sciences, School of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
5
Department of Chemical Engineering and Analytical Science, University of Manchester, Manchester M1 3AL, UK
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2023, 15(3), 819; https://doi.org/10.3390/pharmaceutics15030819
Submission received: 27 January 2023 / Revised: 18 February 2023 / Accepted: 27 February 2023 / Published: 2 March 2023
(This article belongs to the Special Issue Sustainable Materials and Technologies for Drug Delivery and Tissue Engineering)
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Abstract

Silica-based ceramics doped with calcium and magnesium have been proposed as suitable materials for scaffold fabrication. Akermanite (Ca2MgSi2O7) has attracted interest for bone regeneration due to its controllable biodegradation rate, improved mechanical properties, and high apatite-forming ability. Despite the profound advantages, ceramic scaffolds provide weak fracture resistance. The use of synthetic biopolymers such as poly(lactic-co-glycolic acid) (PLGA) as coating materials improves the mechanical performance of ceramic scaffolds and tailors their degradation rate. Moxifloxacin (MOX) is an antibiotic with antimicrobial activity against numerous aerobic and anaerobic bacteria. In this study, silica-based nanoparticles (NPs) enriched with calcium and magnesium, as well as copper and strontium ions that induce angiogenesis and osteogenesis, respectively, were incorporated into the PLGA coating. The aim was to produce composite akermanite/PLGA/NPs/MOX-loaded scaffolds through the foam replica technique combined with the sol–gel method to improve the overall effectiveness towards bone regeneration. The structural and physicochemical characterizations were evaluated. Their mechanical properties, apatite forming ability, degradation, pharmacokinetics, and hemocompatibility were also investigated. The addition of NPs improved the compressive strength, hemocompatibility, and in vitro degradation of the composite scaffolds, resulting in them keeping a 3D porous structure and a more prolonged release profile of MOX that makes them promising for bone regeneration applications.
Keywords: 3D porous scaffolds; foam replica technique; akermanite scaffolds; nanofillers; moxifloxacin-loaded scaffolds 3D porous scaffolds; foam replica technique; akermanite scaffolds; nanofillers; moxifloxacin-loaded scaffolds

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MDPI and ACS Style

Pouroutzidou, G.K.; Papadopoulou, L.; Lazaridou, M.; Tsachouridis, K.; Papoulia, C.; Patsiaoura, D.; Tsamesidis, I.; Chrissafis, K.; Vourlias, G.; Paraskevopoulos, K.M.; et al. Composite PLGA–Nanobioceramic Coating on Moxifloxacin-Loaded Akermanite 3D Porous Scaffolds for Bone Tissue Regeneration. Pharmaceutics 2023, 15, 819. https://doi.org/10.3390/pharmaceutics15030819

AMA Style

Pouroutzidou GK, Papadopoulou L, Lazaridou M, Tsachouridis K, Papoulia C, Patsiaoura D, Tsamesidis I, Chrissafis K, Vourlias G, Paraskevopoulos KM, et al. Composite PLGA–Nanobioceramic Coating on Moxifloxacin-Loaded Akermanite 3D Porous Scaffolds for Bone Tissue Regeneration. Pharmaceutics. 2023; 15(3):819. https://doi.org/10.3390/pharmaceutics15030819

Chicago/Turabian Style

Pouroutzidou, Georgia K., Lambrini Papadopoulou, Maria Lazaridou, Konstantinos Tsachouridis, Chrysanthi Papoulia, Dimitra Patsiaoura, Ioannis Tsamesidis, Konstantinos Chrissafis, George Vourlias, Konstantinos M. Paraskevopoulos, and et al. 2023. "Composite PLGA–Nanobioceramic Coating on Moxifloxacin-Loaded Akermanite 3D Porous Scaffolds for Bone Tissue Regeneration" Pharmaceutics 15, no. 3: 819. https://doi.org/10.3390/pharmaceutics15030819

APA Style

Pouroutzidou, G. K., Papadopoulou, L., Lazaridou, M., Tsachouridis, K., Papoulia, C., Patsiaoura, D., Tsamesidis, I., Chrissafis, K., Vourlias, G., Paraskevopoulos, K. M., Anastasiou, A. D., Bikiaris, D. N., & Kontonasaki, E. (2023). Composite PLGA–Nanobioceramic Coating on Moxifloxacin-Loaded Akermanite 3D Porous Scaffolds for Bone Tissue Regeneration. Pharmaceutics, 15(3), 819. https://doi.org/10.3390/pharmaceutics15030819

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