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Volume 15
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Article

Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica

by
Gabriela Petrișor
1,2,3,
Ludmila Motelica
1,2,3,
Denisa Ficai
2,3,4,
Cornelia-Ioana Ilie
1,2,3,
Roxana Doina Trușcǎ
1,2,3,
Vasile-Adrian Surdu
1,2,3,
Ovidiu-Cristian Oprea
2,3,4,5,*,
Andreea-Luiza Mȋrț
1,2,3,6,
Gabriel Vasilievici
6,
Augustin Semenescu
7,
Anton Ficai
1,2,3,5 and
Lia-Mara Dițu
8,9
1
Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania
2
National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania
3
National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania
4
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania
5
Academy of Romanian Scientists, Ilfov Street 3, 050044 Bucharest, Romania
6
National Institute for Research & Development in Chemistry and Petrochemistry—ICECHIM, 202 Spl. Independentei, 060021 Bucharest, Romania
7
Department Engineering and Management for Transports, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania
8
Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor, 060101 Bucharest, Romania
9
Research Institute of the University of Bucharest, 050095 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Pharmaceutics 2023, 15(2), 660; https://doi.org/10.3390/pharmaceutics15020660
Submission received: 14 January 2023 / Revised: 13 February 2023 / Accepted: 14 February 2023 / Published: 16 February 2023
(This article belongs to the Special Issue Advanced Nanoscience of Biomaterials for Biomedical Applications (Volume II))
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Abstract

Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structure of mesoporous materials, a series of specific techniques were used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) and thermogravimetric analysis (TGA). We monitored the in vitro release of the loaded FA at two different pH values, by using simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Additionally, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Candida albicans ATCC 10231 were used to evaluate the antimicrobial activity of FA loaded mesoporous silica materials. In conclusion such functionalized mesoporous materials can be employed as controlled release systems for polyphenols extracted from natural sources.
Keywords: mesoporous silica; (3-aminopropyl)triethoxysilane; trans-ferulic acid; antimicrobial activity; controlled release mesoporous silica; (3-aminopropyl)triethoxysilane; trans-ferulic acid; antimicrobial activity; controlled release

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MDPI and ACS Style

Petrișor, G.; Motelica, L.; Ficai, D.; Ilie, C.-I.; Trușcǎ, R.D.; Surdu, V.-A.; Oprea, O.-C.; Mȋrț, A.-L.; Vasilievici, G.; Semenescu, A.; et al. Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica. Pharmaceutics 2023, 15, 660. https://doi.org/10.3390/pharmaceutics15020660

AMA Style

Petrișor G, Motelica L, Ficai D, Ilie C-I, Trușcǎ RD, Surdu V-A, Oprea O-C, Mȋrț A-L, Vasilievici G, Semenescu A, et al. Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica. Pharmaceutics. 2023; 15(2):660. https://doi.org/10.3390/pharmaceutics15020660

Chicago/Turabian Style

Petrișor, Gabriela, Ludmila Motelica, Denisa Ficai, Cornelia-Ioana Ilie, Roxana Doina Trușcǎ, Vasile-Adrian Surdu, Ovidiu-Cristian Oprea, Andreea-Luiza Mȋrț, Gabriel Vasilievici, Augustin Semenescu, and et al. 2023. "Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica" Pharmaceutics 15, no. 2: 660. https://doi.org/10.3390/pharmaceutics15020660

APA Style

Petrișor, G., Motelica, L., Ficai, D., Ilie, C.-I., Trușcǎ, R. D., Surdu, V.-A., Oprea, O.-C., Mȋrț, A.-L., Vasilievici, G., Semenescu, A., Ficai, A., & Dițu, L.-M. (2023). Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica. Pharmaceutics, 15(2), 660. https://doi.org/10.3390/pharmaceutics15020660

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