Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents
Round 1
Reviewer 1 Report
1] There are already many similar articles available so what is the significance of your article, highlight the novelty of your work
2] English is not scientifically sound. In some cases sentences formation is correct. Also, avoid the use of third person like "we"
3] Author must provide a new section about chanleenges and their appropirate solutions as well
4] Increse the rsolution of Figure 3 and 4. Also, draw the structure using ChemDraw
5] Rationale of sudy is missing. Authors should provide one paragraph about this in end of introduction
Author Response
We welcome the constructive comments of the reviewers and thank them for assisting us to improve our manuscript. We have extensively revised the manuscript with attention to English language editing and highlighted (yellow) the significant changes to the text in response to the Editor’s and Reviewers’ comments.
Reviewer #1:
We thank the reviewer for his/her positive response.
- There are already many similar articles available so what is the significance of your article, highlight the novelty of your work
RESPONSE: The previously published review articles and book chapters were focused on the modifications of xanthan gum (XG) to improve its physicochemical properties and have highlighted its applications as a drug delivery carrier particularly using conventional formulations. However, our review is focused on describing the application of XG in designing disease-specific drug delivery systems. Furthermore, it includes the delivery of genetic materials, peptides, and proteins using XG-based carriers.
- English is not scientifically sound. In some cases, sentences formation is correct. Also, avoid the use of third person like "we"
RESPONSE: The revised manuscript incorporates the suggested revisions and improved language.
- Author must provide a new section about challenges and their appropriate solutions as well
RESPONSE: Challenges in the use of XG and their probable solutions have been incorporated into the conclusion and future prospective section.
- Increase the resolution of Figure 3 and 4. Also, draw the structure using ChemDraw
RESPONSE: The images (Figures 3 and 4) with improved resolution are now provided. The chemical structures are drawn using ChemDraw.
- The rationale of the study is missing. Authors should provide one paragraph about this at end of the introduction
RESPONSE: We have incorporated the rationale of the study at the end of the introduction in the revised manuscript.
Reviewer 2 Report
Advances in Xantan Gum-based system for the delivery of the therapeutic agents is an interesting paper. The manuscript has the potential for publication consideration but before that, some issues must be solved:
Major:
X. campestris is a plant pathogen that represents an important economic loss for crop production. The authors should add a paragraph in the introduction what are disadvantages of X. campestris.
Use of Xanthan gum for probiotics – which strains of probiotic bacteria? Be more specific.
Use of Xanthan gum for antiviral drugs – which viruses? Be more specific.
Line 36: Explain what is predictable outcomes in the human body.
Section 5.1: Add if XG is antibacterial or is just a deliverer.
Line 466: Check if the drug can have pH 1.2.
Minor:
The authors should check and revise the manuscript so that the names of bacterial strains are written correctly – in Italics. Check the entire manuscript.
Line 48, 83: Check the molecular weight.
Line 208: check and correct the ions
Line 323 and 329: correct the chemical formulas.
Author Response
We welcome the constructive comments of the reviewers and thank them for assisting us to improve our manuscript. We have extensively revised the manuscript with attention to English language editing and highlighted (yellow) the significant changes to the text in response to the Editor’s and Reviewers’ comments.
Reviewer #2: Advances in Xanthan Gum-based system for the delivery of the therapeutic agents is an interesting paper. The manuscript has the potential for publication consideration but before that, some issues must be solved:
Major:
- campestris is a plant pathogen that represents an important economic loss for crop production. The authors should add a paragraph in the introduction what are disadvantages of X. campestris.
RESPONSE: In the introduction, the disadvantages of X. campestris are added in the revised manuscript.
- Use of Xanthan gum for probiotics – which strains of probiotic bacteria? Be more specific.
RESPONSE: Xanthan gum is used as a prebiotic with certain probiotics. The specific probiotic bacteria (Bifidobacterium bifidum) have been mentioned in the revised manuscript.
- Use of Xanthan gum for antiviral drugs – which viruses? Be more specific.
RESPONSE: The specific viruses have been mentioned. Please refer to lines 311, 342, and Table 2 (Sr. No. 3 & 10), in the revised manuscript.
- Line 36: Explain what is predictable outcomes in the human body.
RESPONSE: Predictable outcomes in the body meant the biocompatibility and complete biodegradability of the nanoparticles made up of natural polymers in comparison to those prepared using synthetic polymers. The explanation for the same has been incorporated in the revised manuscript.
- Section 5.1: Add if XG is antibacterial or is just a deliverer.
RESPONSE: Xanthan gum is used as a carrier for the delivery of antimicrobial drugs. The sentence is revised to clarify this point.
- Line 466: Check if the drug can have pH 1.2.
RESPONSE: Herein, pH 1.2 represents the pH of the gastric fluid.
Minor
- The authors should check and revise the manuscript so that the names of bacterial strains are written correctly – in Italics. Check the entire manuscript.
RESPONSE: The names of bacterial strains have been corrected.
- Line 48, 83: Check the molecular weight.
RESPONSE: The typographical error in the molecular weight of XG has been corrected.
- Line 208: check and correct the ions
RESPONSE: The ions are checked and have been edited.
- Line 323 and 329: correct the chemical formulas.
RESPONSE: The chemical formulas have been edited.
Reviewer 3 Report
Jahav et al described the applications of xanthan gum (XG), in the delivery of various therapeutic agents such as drugs, genetic materials, proteins, and peptides. The paper is well-organized and written. However, there are still some problems in the article. The specific comments are as follows:
1. is Figure 3 a reused figure? If yes, the reference source should be indicated, and a picture with better resolution should be replaced.
2. The structure of Fig. 2 should be reorganized to accurately show the conformational change of xanthan gum.
3.In 5.7, furosemide is not an anti-inflammatory drug and should not be included in this scope. It should be corrected.
4.It is suggested to delete the title 5.5. Other classifications in this document are based on the type of disease. 5.5 is "gastrointestinal drug delivery", and it is suggested to list this part in 5.7.
5.The format of the references cited in this paper is not uniform and need to be revised.
Author Response
We welcome the constructive comments of the reviewers and thank them for assisting us to improve our manuscript. We have extensively revised the manuscript with attention to English language editing and highlighted (yellow) the significant changes to the text in response to the Editor’s and Reviewers’ comments.
Reviewer #3: Jadav et al described the applications of xanthan gum (XG), in the delivery of various therapeutic agents such as drugs, genetic materials, proteins, and peptides. The paper is well-organized and written. However, there are still some problems in the article. The specific comments are as follows:
- is Figure 3 a reused figure? If yes, the reference source should be indicated, and a picture with better resolution should be replaced.
RESPONSE: Yes, Figure 3 is a reused figure after receiving the reprint permission from the publisher. The reference number is cited in the figure legend. For a better resolution of the image, we obtained the original copy of the figure from the authors which is now used.
- The structure of Fig. 2 should be reorganized to accurately show the conformational change of xanthan gum
RESPONSE: The structure of the xanthan gum is reorganized with appropriate conformation in the revised manuscript.
- In 5.7, furosemide is not an anti-inflammatory drug and should not be included in this scope. It should be corrected
RESPONSE: Yes, furosemide is a diuretic drug and therefore, it has been removed from the anti-inflammatory section.
- It is suggested to delete the title 5.5. Other classifications in this document are based on the type of disease. 5.5 is "gastrointestinal drug delivery", and it is suggested to list this part in 5.7.
RESPONSE: As suggested by the reviewer, Section 5.5 “gastrointestinal drug delivery” is removed and the content is added under section 5.7 in the revised manuscript.
- The format of the references cited in this paper is not uniform and need to be revised.
RESPONSE: The format of the references is made uniform and as per the Journal’s guideline.
Round 2
Reviewer 1 Report
It can be accepted now
Reviewer 2 Report
The authors corrected all the isues. I recommend publication.
