Next Article in Journal
Targeted Endoradiotherapy with Lu2O3-iPSMA/-iFAP Nanoparticles Activated by Neutron Irradiation: Preclinical Evaluation and First Patient Image
Previous Article in Journal
An Overview of siRNA Delivery Strategies for Urological Cancers
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceutics
Volume 14
Issue 4
10.3390/pharmaceutics14040719
pharmaceutics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Diphlorethohydroxycarmalol Derived from Ishige okamurae Improves Behavioral and Physiological Responses of Muscle Atrophy Induced by Dexamethasone in an In-Vivo Model

by
Bomi Ryu
1,*,†,
Seyeon Oh
2,†,
Hye-Won Yang
1,
Batsukh Sosorburam
2,3,
Dong-Min Chung
4,
Minyoung Seo
4,
Shin-Jae Park
4,
Kyunghee Byun
2,3,* and
You-Jin Jeon
1,5,*
1
Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, Jeju 63243, Korea
2
Functional Cellular Networks Laboratory, Department of Medicine, Graduate School, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea
3
Department of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Korea
4
Shinwoo Co., Ltd., Jinju 52839, Korea
5
Marine Science Institute, Jeju National University, Jeju 63333, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceutics 2022, 14(4), 719; https://doi.org/10.3390/pharmaceutics14040719
Submission received: 17 February 2022 / Revised: 17 March 2022 / Accepted: 21 March 2022 / Published: 27 March 2022
(This article belongs to the Topic Advances in Natural Products from Plants and Associated Microbes)
Browse Figures
Versions Notes

Abstract

Muscle atrophy refers to the loss of skeletal muscle mass, myofiber size, and related physical functions such as walking speed or grip strength caused by aging or a lack of physical activity due to injury or illness and can also be attributed to excessive exposure to corticosteroids. Ishige okamurae (IO) and its active component, diphlorethohydroxycarmalol (DPHC), have been known to improve glucose homeostasis by controlling the contraction of skeletal muscles. Based on this idea, we hypothesized that the effects of DPHC and IO extract on muscle metabolism are associated with their role in improving muscle physical function. This study assessed the effects of DPHC or IO extract on muscle behavioral responses with their metabolic properties in muscle atrophy induced by glucocorticoids and dexamethasone (DEX) in vivo. In addition to the improvement in muscle behavioral response by DPHC or IO extract, the loss of muscle fiber and the related metabolic properties by DEX exposure in the gastrocnemius and soleus of calf muscle was prevented. These findings suggest that IO extract and its active component DPHC can potentially prevent muscle atrophy caused by exposure to corticosteroids and could be used to treat reverse skeletal atrophy.
Keywords: muscle atrophy; Ishige okamurae (IO); diphlorethohydroxycarmalol (DPHC); dexamethasone (DEX); physical function; metabolic property muscle atrophy; Ishige okamurae (IO); diphlorethohydroxycarmalol (DPHC); dexamethasone (DEX); physical function; metabolic property
Graphical Abstract

Share and Cite

MDPI and ACS Style

Ryu, B.; Oh, S.; Yang, H.-W.; Sosorburam, B.; Chung, D.-M.; Seo, M.; Park, S.-J.; Byun, K.; Jeon, Y.-J. Diphlorethohydroxycarmalol Derived from Ishige okamurae Improves Behavioral and Physiological Responses of Muscle Atrophy Induced by Dexamethasone in an In-Vivo Model. Pharmaceutics 2022, 14, 719. https://doi.org/10.3390/pharmaceutics14040719

AMA Style

Ryu B, Oh S, Yang H-W, Sosorburam B, Chung D-M, Seo M, Park S-J, Byun K, Jeon Y-J. Diphlorethohydroxycarmalol Derived from Ishige okamurae Improves Behavioral and Physiological Responses of Muscle Atrophy Induced by Dexamethasone in an In-Vivo Model. Pharmaceutics. 2022; 14(4):719. https://doi.org/10.3390/pharmaceutics14040719

Chicago/Turabian Style

Ryu, Bomi, Seyeon Oh, Hye-Won Yang, Batsukh Sosorburam, Dong-Min Chung, Minyoung Seo, Shin-Jae Park, Kyunghee Byun, and You-Jin Jeon. 2022. "Diphlorethohydroxycarmalol Derived from Ishige okamurae Improves Behavioral and Physiological Responses of Muscle Atrophy Induced by Dexamethasone in an In-Vivo Model" Pharmaceutics 14, no. 4: 719. https://doi.org/10.3390/pharmaceutics14040719

APA Style

Ryu, B., Oh, S., Yang, H.-W., Sosorburam, B., Chung, D.-M., Seo, M., Park, S.-J., Byun, K., & Jeon, Y.-J. (2022). Diphlorethohydroxycarmalol Derived from Ishige okamurae Improves Behavioral and Physiological Responses of Muscle Atrophy Induced by Dexamethasone in an In-Vivo Model. Pharmaceutics, 14(4), 719. https://doi.org/10.3390/pharmaceutics14040719

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop