Development of a Novel Vaginal Drug Delivery System to Control Time of Farrowing and Allow Supervision of Piglet Delivery
, Kate J. Plush 2, Sadikalmahdi Abdella 3, Yunmei Song 3 and Sanjay Garg 3Round 1
Reviewer 1 Report
This manuscript describes IR and CR vaginal tablets to control time of farrowing in sows. The overall merit of the manuscript is above average. However, the manuscript contains numerous errors (see my attached pdf) that need to be corrected before I will recommend that it be accepted for publication.
Comments for author File: 
Comments.pdf
Author Response
Thankyou for your review, please see attached document with amendments
Author Response File: 
Author Response.docx
Reviewer 2 Report
Lines14-16: Review sentence for clarity
Line 22: Change “In vivo” to “in vivo”
Line 24: Clarify the IR tablet was administered at two time points
Line 65 and 68: Should “RR” be “IR”?
Line 94: Check sentence for clarity
Line 119: Should this be Table 1?
Line 274: Capitalize “makoid”
Line 303: Define “a, b, c” in Figure 10
Line 328: Change “suppository” to tablet
Line 332: Define “ a and b” in Figure 11
Line 395: Often when administering a drug via the vaginal mucosa, systemic drug levels will be low. This can be considered a positive that systemic levels are low.
It would be worthwhile to include more information on the current treatments for inducing partition and the drawbacks to the current standard.
Were any vaginal irritation studies conducted with the tables? The rabbit model could be used to assess vaginal irritation and also per PK. It would be a way to demonstrate low systemic exposure in plasma, but measurable local tissue concentrations.
Author Response
Thankyou for your edits, please see attached document for amendments and responses
Author Response File: Author Response.docx
Round 2
Reviewer 1 Report
The authors did a nice job of revising the manuscript.
However, I have two comments on the latest draft:
Line 16: Why suppositories? You developed tablets.
Line 47: The text in Figure 1 is out of focus. It needs to be revised.
Author Response
Thankyou, line 16 and Figure 1 has been updated
Reviewer 2 Report
Thank you for addressing each of my comments. Everything was appropriately revised as needed.
Author Response
Thankyou again, updated version has been submitted
