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Volume 14
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Article

Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting

by
Shengli Wan
1,2,3,4,†,
Yuesong Wu
4,5,†,
Qingze Fan
2,4,
Gang Yang
2,
Haiyang Hu
4,5,
Singkome Tima
1,6,
Sawitree Chiampanichayakul
1,
Songyot Anuchapreeda
1,6,* and
Jianming Wu
3,5,*
1
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
2
Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
3
School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China
4
School of Pharmacy, Southwest Medical University, Luzhou 646000, China
5
Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Southwest Medical University, Luzhou 646000, China
6
Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai 50200, Thailand
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceutics 2022, 14(12), 2614; https://doi.org/10.3390/pharmaceutics14122614
Submission received: 17 October 2022 / Revised: 20 November 2022 / Accepted: 22 November 2022 / Published: 26 November 2022
(This article belongs to the Section Biologics and Biosimilars)
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Abstract

Cancer is a major threat to the health of humans. Recently, various natural products including curcumin (CCM) have attracted enormous interest for efficacious cancer therapy. However, natural therapeutic agents still encounter certain challenges such as rapid clearance, low bioavailability, and poor tumor targeting. Recently, the platelet membrane (PM) camouflaged nanoparticle has provided a promising solution for cancer targeting therapy. Nevertheless, only limited efforts have been dedicated to systematically explore the mechanism of affinity between PM bioinspired nanoparticles and various tumor cells. Herein, a CCM-encapsulated platelet membrane biomimetic lipid vesicle (CCM@PL) with a size of 163.2 nm, zeta potential of −31.8 mV and encapsulation efficiency of 93.62% was developed. The values of the area under the concentration-time curve and mean residence time for CCM@PL were 3.08 times and 3.04 times those of CCM, respectively. Furthermore, this PM biomimetic carrier showed an excellent affinity against Huh-7, SK-OV-3 and MDA-MB-231 cell lines due to the biomolecular interaction between P-selectin on the PM and tumoral CD44 receptors. In addition, CCM@PL displayed enhanced cytotoxicity compared with free CCM and the synthetic formulation. Overall, our results suggest that this developed PM biomimetic lipid nanovector has great potential for targeted cancer treatment and natural components delivery.
Keywords: platelet membrane; lipid nanovector; targeted cancer therapy; curcumin platelet membrane; lipid nanovector; targeted cancer therapy; curcumin

Share and Cite

MDPI and ACS Style

Wan, S.; Wu, Y.; Fan, Q.; Yang, G.; Hu, H.; Tima, S.; Chiampanichayakul, S.; Anuchapreeda, S.; Wu, J. Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting. Pharmaceutics 2022, 14, 2614. https://doi.org/10.3390/pharmaceutics14122614

AMA Style

Wan S, Wu Y, Fan Q, Yang G, Hu H, Tima S, Chiampanichayakul S, Anuchapreeda S, Wu J. Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting. Pharmaceutics. 2022; 14(12):2614. https://doi.org/10.3390/pharmaceutics14122614

Chicago/Turabian Style

Wan, Shengli, Yuesong Wu, Qingze Fan, Gang Yang, Haiyang Hu, Singkome Tima, Sawitree Chiampanichayakul, Songyot Anuchapreeda, and Jianming Wu. 2022. "Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting" Pharmaceutics 14, no. 12: 2614. https://doi.org/10.3390/pharmaceutics14122614

APA Style

Wan, S., Wu, Y., Fan, Q., Yang, G., Hu, H., Tima, S., Chiampanichayakul, S., Anuchapreeda, S., & Wu, J. (2022). Bioinspired Platelet-like Nanovector for Enhancing Cancer Therapy via P-Selectin Targeting. Pharmaceutics, 14(12), 2614. https://doi.org/10.3390/pharmaceutics14122614

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