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Article

The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study

1
Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, SI-1000 Ljubljana, Slovenia
2
Jožef Stefan Institute, Jamova Cesta 39, SI-1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Academic Editor: Marzia Cirri
Pharmaceutics 2021, 13(8), 1177; https://doi.org/10.3390/pharmaceutics13081177
Received: 14 July 2021 / Revised: 28 July 2021 / Accepted: 28 July 2021 / Published: 30 July 2021
(This article belongs to the Section Pharmaceutical Technology, Manufacturing and Devices)
The objective of this study was to explore the possible use of a new combination of two excipients, i.e., nanocrystalline cellulose (NCC) and macroporous silica (MS), as matrix materials for the compounding of dry emulsion systems and the effects these two excipients have on the characteristics of dry emulsion powders produced by the spray drying process. A previously developed liquid O/W nanoemulsion, comprised of simvastatin, 1-oleoyl-rac-glycerol, Miglyol 812 and Tween 20, was employed. In order to comprehend the effects that these two matrix formers have on the spray drying process and on dry emulsion powder characteristics, alone and in combination, a DoE (Design of Experiment) approach was used. The physicochemical properties of dry emulsion samples were characterised by atomic force microscopy, scanning electron microscopy, mercury intrusion porosimetry, energy-dispersive X-ray spectroscopy and laser diffraction analysis. Additionally, total release and dissolution experiments were performed to assess drug release from multiple formulations. It was found that the macroporous silica matrix drastically improved flow properties of dry emulsion powders; however, it partially trapped the oil—drug mixture inside the pores and hindered complete release. NCC showed its potential to reduce oil entrapment in MS, but because of its rod-shaped particles deposited on the MS surface, powder flowability was deteriorated. View Full-Text
Keywords: simvastatin; dry emulsion; lipid-based drug delivery systems; nanocrystalline cellulose; macroporous silica; spray drying; flowability; DoE simvastatin; dry emulsion; lipid-based drug delivery systems; nanocrystalline cellulose; macroporous silica; spray drying; flowability; DoE
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MDPI and ACS Style

Pohlen, M.; Pirker, L.; Dreu, R. The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study. Pharmaceutics 2021, 13, 1177. https://doi.org/10.3390/pharmaceutics13081177

AMA Style

Pohlen M, Pirker L, Dreu R. The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study. Pharmaceutics. 2021; 13(8):1177. https://doi.org/10.3390/pharmaceutics13081177

Chicago/Turabian Style

Pohlen, Mitja, Luka Pirker, and Rok Dreu. 2021. "The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study" Pharmaceutics 13, no. 8: 1177. https://doi.org/10.3390/pharmaceutics13081177

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