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Review

Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

1
Instituto de Biologia Experimental e Tecnológica (iBET), Apartado 12, 2781-901 Oeiras, Portugal
2
Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal
3
CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Ariane Leite Rozza
Pharmaceutics 2021, 13(7), 991; https://doi.org/10.3390/pharmaceutics13070991
Received: 26 May 2021 / Revised: 18 June 2021 / Accepted: 22 June 2021 / Published: 30 June 2021
Inflammation is a crucial and complex process that reestablishes the physiological state after a noxious stimulus. In pathological conditions the inflammatory state may persist, leading to chronic inflammation and causing tissue damage. Sesquiterpene lactones (SLs) are composed of a large and diverse group of highly bioactive plant secondary metabolites, characterized by a 15-carbon backbone structure. In recent years, the interest in SLs has risen due to their vast array of biological activities beneficial for human health. The anti-inflammatory potential of these compounds results from their ability to target and inhibit various key pro-inflammatory molecules enrolled in diverse inflammatory pathways, and prevent or reduce the inflammatory damage on tissues. Research on the anti-inflammatory mechanisms of SLs has thrived over the last years, and numerous compounds from diverse plants have been studied, using in silico, in vitro, and in vivo assays. Besides their anti-inflammatory potential, their cytotoxicity, structure–activity relationships, and pharmacokinetics have been investigated. This review aims to gather the most relevant results and insights concerning the anti-inflammatory potential of SL-rich extracts and pure SLs, focusing on their effects in different inflammatory pathways and on different molecular players. View Full-Text
Keywords: anti-inflammatory; bioactivity; sesquiterpene lactone-rich natural extracts; germacranolides; guaianolides; eudesmanolides; heliangolides; pseudoguainolides; inflammatory pathway; NF-κB; pro-inflammatory mediators anti-inflammatory; bioactivity; sesquiterpene lactone-rich natural extracts; germacranolides; guaianolides; eudesmanolides; heliangolides; pseudoguainolides; inflammatory pathway; NF-κB; pro-inflammatory mediators
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MDPI and ACS Style

Matos, M.S.; Anastácio, J.D.; Nunes dos Santos, C. Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation. Pharmaceutics 2021, 13, 991. https://doi.org/10.3390/pharmaceutics13070991

AMA Style

Matos MS, Anastácio JD, Nunes dos Santos C. Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation. Pharmaceutics. 2021; 13(7):991. https://doi.org/10.3390/pharmaceutics13070991

Chicago/Turabian Style

Matos, Melanie S., José D. Anastácio, and Cláudia Nunes dos Santos. 2021. "Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation" Pharmaceutics 13, no. 7: 991. https://doi.org/10.3390/pharmaceutics13070991

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