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Article

Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using Poloxamer 407-Based Solid Dispersion via the Anti-Solvent Method

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College of Pharmacy, Ajou University, Suwon 16499, Korea
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School of Chemical and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China
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College of Pharmaceutical Science, Soochow University, Suzhou 215123, China
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Students Innovation and Entrepreneurship Center, Jilin Institute of Chemical Technology, Jilin 132022, China
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Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2H7, Canada
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Institute of Pharmaceutical Science and Technology, Ajou University, Suwon 16499, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas Rades
Pharmaceutics 2021, 13(5), 662; https://doi.org/10.3390/pharmaceutics13050662
Received: 18 March 2021 / Revised: 20 April 2021 / Accepted: 25 April 2021 / Published: 5 May 2021
(This article belongs to the Special Issue Solubilization and Controlled Release of Poorly Water-Soluble Drugs)
This study aimed to investigate the role of micellization of sodium lauryl sulfate (SLS) in poloxamer 407 (POX)-based solid dispersions (POX-based SDs) using the anti-solvent method in enhancing the dissolution rate of practically water-insoluble cilostazol (CLT). Herein, SLS was incorporated into CLT-loaded SDs, at a weight ratio of 50:50:10 of CLT, POX, and SLS by three different methods: anti-solvent, fusion (60 °C), and solvent (ethanol) evaporation. The SDs containing micellar SLS in the anti-solvent method were superior in the transformation of the crystalline form of the drug into a partial amorphous state. It was notable that there was an existence of a hydrophobic interaction between the surfactant and the hydrophobic regions of polymer chain via non-covalent bonding and the adsorption of micellar SLS to the POX-based SDs matrix. Moreover, SLS micellization via the anti-solvent method was effectively interleaved in SDs and adhered by the dissolved CLT, which precluded drug particles from aggregation and recrystallization, resulting in improved SD wettability (lower contact angle) and reduced particle size and dissolution rate. In contrast, SDs without micellar SLS prepared by the solvent method exerted drug recrystallization and an increase of particle size, resulting in decreased dissolution. Incorporation of surfactant below or above critical micellar concentration (CMC) in SDs using the anti-solvent method should be considered in advance. Dissolution results showed that the pre-added incorporation of micellar SLS into POX-based SDs using the anti-solvent method could provide a way of a solubilization mechanism to enhance the dissolution rate of poorly water-soluble drugs. View Full-Text
Keywords: water-insoluble cilostazol; solid dispersion; anti-solvent method; micellization of sodium lauryl sulfate; enhanced dissolution; partial amorphous state; molecular interaction; particle size; contact angle water-insoluble cilostazol; solid dispersion; anti-solvent method; micellization of sodium lauryl sulfate; enhanced dissolution; partial amorphous state; molecular interaction; particle size; contact angle
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MDPI and ACS Style

Jin, G.; Ngo, H.V.; Cui, J.-H.; Wang, J.; Park, C.; Lee, B.-J. Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using Poloxamer 407-Based Solid Dispersion via the Anti-Solvent Method. Pharmaceutics 2021, 13, 662. https://doi.org/10.3390/pharmaceutics13050662

AMA Style

Jin G, Ngo HV, Cui J-H, Wang J, Park C, Lee B-J. Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using Poloxamer 407-Based Solid Dispersion via the Anti-Solvent Method. Pharmaceutics. 2021; 13(5):662. https://doi.org/10.3390/pharmaceutics13050662

Chicago/Turabian Style

Jin, Gang, Hai V. Ngo, Jing-Hao Cui, Jie Wang, Chulhun Park, and Beom-Jin Lee. 2021. "Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using Poloxamer 407-Based Solid Dispersion via the Anti-Solvent Method" Pharmaceutics 13, no. 5: 662. https://doi.org/10.3390/pharmaceutics13050662

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