New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery
1
Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania
2
Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania
3
Academy of Romanian Scientists, Ilfov No. 3, 50044 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editors: Aristides D. Tagalakis, Dimitrios A. Lamprou and Cynthia Yu-Wai-Man
Pharmaceutics 2021, 13(12), 2053; https://doi.org/10.3390/pharmaceutics13122053
Received: 29 October 2021
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Revised: 26 November 2021
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Accepted: 29 November 2021
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Published: 1 December 2021
(This article belongs to the Special Issue Novel Nanoparticles for Targeted Delivery of Therapeutic Nucleic Acids)
Nucleic acids represent a promising lead for engineering the immune system. However, naked DNA, mRNA, siRNA, and other nucleic acids are prone to enzymatic degradation and face challenges crossing the cell membrane. Therefore, increasing research has been recently focused on developing novel delivery systems that are able to overcome these drawbacks. Particular attention has been drawn to designing lipid and polymer-based nanoparticles that protect nucleic acids and ensure their targeted delivery, controlled release, and enhanced cellular uptake. In this respect, this review aims to present the recent advances in the field, highlighting the possibility of using these nanosystems for therapeutic and prophylactic purposes towards combatting a broad range of infectious, chronic, and genetic disorders.
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Keywords:
therapeutic nucleic acids; TNA delivery; lipid-based delivery systems; polymer-based delivery systems; lipid-polymer hybrid-based delivery systems; targeted delivery
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MDPI and ACS Style
Niculescu, A.-G.; Bîrcă, A.C.; Grumezescu, A.M. New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery. Pharmaceutics 2021, 13, 2053. https://doi.org/10.3390/pharmaceutics13122053
AMA Style
Niculescu A-G, Bîrcă AC, Grumezescu AM. New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery. Pharmaceutics. 2021; 13(12):2053. https://doi.org/10.3390/pharmaceutics13122053
Chicago/Turabian StyleNiculescu, Adelina-Gabriela, Alexandra C. Bîrcă, and Alexandru M. Grumezescu. 2021. "New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery" Pharmaceutics 13, no. 12: 2053. https://doi.org/10.3390/pharmaceutics13122053
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