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Article

Anti-Irritant Strategy against Retinol Based on the Genetic Analysis of Korean Population: A Genetically Guided Top–Down Approach

Department of Core Technology, LG Household and Health Care R&D Center, Seoul 07795, Korea
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Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Marie Alexandrine Bolzinger
Pharmaceutics 2021, 13(12), 2006; https://doi.org/10.3390/pharmaceutics13122006 (registering DOI)
Received: 13 September 2021 / Revised: 11 November 2021 / Accepted: 18 November 2021 / Published: 25 November 2021
Retinol, one of the most powerful cosmetic materials for anti-aging supported by a solid scientific background, exhibits a wide range of type and severity of irritation while showing limited user compliance. The lack of understanding of the mechanism of retinol-induced irritation has been the main hurdle in the development of anti-irritation strategies. Here, we identified 30 genetic markers related to the susceptibility to retinol-induced irritation in the Korean population. Based on the genetic analysis, a novel formula against retinol-induced irritation was developed, which mitigated the molecular pathogenesis—as indicated by the genetic markers—of the retinol-induced irritation. In human tests, this formula effectively decreased retinol-induced irritation. Furthermore, a polygenic risk score model for irritation was constructed and validated. Our comprehensive approach for the analysis of retinol-induced irritation will not only aid the development of anti-irritation strategies to ensure higher user compliance but also contribute to improving the current knowledge about the biological effects of retinoids. View Full-Text
Keywords: retinol; retinoid; cosmetics; anti-irritation; genetically customized; single nucleotide polymorphisms retinol; retinoid; cosmetics; anti-irritation; genetically customized; single nucleotide polymorphisms
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MDPI and ACS Style

Kang, S.; Kim, K.; Jun, S.-H.; Lee, S.; Kim, J.; Shin, J.-G.; Kim, Y.; Kim, M.; Park, S.-G.; Kang, N.-G. Anti-Irritant Strategy against Retinol Based on the Genetic Analysis of Korean Population: A Genetically Guided Top–Down Approach. Pharmaceutics 2021, 13, 2006. https://doi.org/10.3390/pharmaceutics13122006

AMA Style

Kang S, Kim K, Jun S-H, Lee S, Kim J, Shin J-G, Kim Y, Kim M, Park S-G, Kang N-G. Anti-Irritant Strategy against Retinol Based on the Genetic Analysis of Korean Population: A Genetically Guided Top–Down Approach. Pharmaceutics. 2021; 13(12):2006. https://doi.org/10.3390/pharmaceutics13122006

Chicago/Turabian Style

Kang, Seongsu, Kyunghoe Kim, Seung-Hyun Jun, Seonju Lee, Juhyun Kim, Joong-Gon Shin, Yunkwan Kim, Mina Kim, Sun-Gyoo Park, and Nae-Gyu Kang. 2021. "Anti-Irritant Strategy against Retinol Based on the Genetic Analysis of Korean Population: A Genetically Guided Top–Down Approach" Pharmaceutics 13, no. 12: 2006. https://doi.org/10.3390/pharmaceutics13122006

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