Next Article in Journal
A Novel Three-Polysaccharide Blend In Situ Gelling Powder for Wound Healing Applications
Previous Article in Journal
Intratracheal Administration of Chloroquine-Loaded Niosomes Minimize Systemic Drug Exposure
Previous Article in Special Issue
Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral Drug Bioavailability and Patient Compliance Implications
Article

Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms

1
Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham, Nottingham NG7 2RD, UK
2
Centre for Additive Manufacturing, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK
*
Authors to whom correspondence should be addressed.
Academic Editor: Marta González-Álvarez
Pharmaceutics 2021, 13(10), 1679; https://doi.org/10.3390/pharmaceutics13101679
Received: 21 August 2021 / Revised: 20 September 2021 / Accepted: 27 September 2021 / Published: 14 October 2021
(This article belongs to the Special Issue Controlled Delivery Formulations (Volume II))
One of the most striking characteristics of 3D printing is its capability to produce multi-material objects with complex geometry. In pharmaceutics this translates to the possibility of dosage forms with multi-drug loading, tailored dosing and release. We have developed a novel dual material hot-melt inkjet 3D printing system which allows for precisely controlled multi-material solvent free inkjet printing. This reduces the need for time-consuming exchanges of printable inks and expensive post processing steps. With this printer, we show the potential for design of printed dosage forms for tailored drug release, including single and multi-material complex 3D patterns with defined localised drug loading where a drug-free ink is used as a release-retarding barrier. For this, we used Compritol HD5 ATO (matrix material) and Fenofibrate (model drug) to prepare both drug-free and drug-loaded inks with drug concentrations varying between 5% and 30% (w/w). The printed constructs demonstrated the required physical properties and displayed immediate, extended, delayed and pulsatile drug release depending on drug localisation inside of the printed formulations. For the first time, this paper demonstrates that a commonly used pharmaceutical lipid, Compritol HD5 ATO, can be printed via hot-melt inkjet printing as single ink material, or in combination with a drug, without the need for additional solvents. Concurrently, this paper demonstrates the capabilities of dual material hot-melt inkjet 3D printing system to produce multi-material personalised solid dosage forms. View Full-Text
Keywords: 3D printing; hotmelt inkjet printing; solid dosage form; polypill; multi-material tablets; drug delivery 3D printing; hotmelt inkjet printing; solid dosage form; polypill; multi-material tablets; drug delivery
Show Figures

Graphical abstract

MDPI and ACS Style

Lion, A.; Wildman, R.D.; Alexander, M.R.; Roberts, C.J. Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms. Pharmaceutics 2021, 13, 1679. https://doi.org/10.3390/pharmaceutics13101679

AMA Style

Lion A, Wildman RD, Alexander MR, Roberts CJ. Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms. Pharmaceutics. 2021; 13(10):1679. https://doi.org/10.3390/pharmaceutics13101679

Chicago/Turabian Style

Lion, Anna, Ricky D. Wildman, Morgan R. Alexander, and Clive J. Roberts. 2021. "Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms" Pharmaceutics 13, no. 10: 1679. https://doi.org/10.3390/pharmaceutics13101679

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop