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Article

Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains

1
School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia 38402-018, Brazil
2
Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
3
Institute of Biotechnology, Federal University of Uberlândia, Uberlândia 38405-319, Brazil
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(8), 769; https://doi.org/10.3390/pharmaceutics12080769
Received: 14 July 2020 / Revised: 3 August 2020 / Accepted: 8 August 2020 / Published: 14 August 2020
This work describes the development of a gastroresistant antimicrobial formulation composed of two carriers, pectin and liposomes, intended to improve the efficiency of norfloxacin (NOR) against multi-resistant bacterial strains. The formulations showed physicochemical stability for 180 days (4 °C) in terms of size, polydispersity, and zeta potential of the vesicles, prolonging the in vitro release of NOR for 11 h. The hybrid nanocarriers improved the in vitro antimicrobial activity against different multidrug-resistant bacterial strains, such as Salmonella sp., Pseudomonasaeruginosa, E. coli and Campylobacterjejuni, in comparison to commercial NOR and liposomal suspensions. The in vivo toxicity assay in chicken embryos revealed that the hybrid systems were not toxic in any of the different parameters analyzed, a result also corroborated by the analyses of biochemical biomarkers of the chicken-embryos liver function. View Full-Text
Keywords: drug delivery; hybrid formulations; liposomes; biopolymers; fluoroquinolones; multidrug resistance drug delivery; hybrid formulations; liposomes; biopolymers; fluoroquinolones; multidrug resistance
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MDPI and ACS Style

Ribeiro, L.N.d.M.; de Paula, E.; Rossi, D.A.; Monteiro, G.P.; Júnior, E.C.V.; Silva, R.R.; Franco, R.R.; Espíndola, F.S.; Goulart, L.R.; Fonseca, B.B. Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains. Pharmaceutics 2020, 12, 769. https://doi.org/10.3390/pharmaceutics12080769

AMA Style

Ribeiro LNdM, de Paula E, Rossi DA, Monteiro GP, Júnior ECV, Silva RR, Franco RR, Espíndola FS, Goulart LR, Fonseca BB. Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains. Pharmaceutics. 2020; 12(8):769. https://doi.org/10.3390/pharmaceutics12080769

Chicago/Turabian Style

Ribeiro, Lígia N.d.M.; de Paula, Eneida; Rossi, Daise A.; Monteiro, Guilherme P.; Júnior, Edson C.V.; Silva, Rogério R.; Franco, Rodrigo R.; Espíndola, Foued S.; Goulart, Luiz R.; Fonseca, Belchiolina B. 2020. "Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains" Pharmaceutics 12, no. 8: 769. https://doi.org/10.3390/pharmaceutics12080769

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