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Article

A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and Chemotherapy

1
Department of Biochemical Science and Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan
2
Graduate Institute of Biomedical Materials and Engineering, Graduate School of Dentistry, Taipei Medical University, Taipei 11043, Taiwan
3
Division of Plastic Surgery, Department of Surgery, Taipei Medical University Hospital and College of Medicine, Taipei Medical University, Taipei 110, Taiwan
4
Division of Plastic Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei 10012, Taiwan
5
Department of Neurology, National Taiwan University Hospital, 7, Chung-Shan South Road, Taipei 10012, Taiwan
6
Department of Neurology, National Taiwan University Hospital Yunlin Branch, 579, Sec. 2, Yunlin Road, Douliu City, Yunlin 640, Taiwan
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(4), 317; https://doi.org/10.3390/pharmaceutics12040317
Received: 10 March 2020 / Revised: 28 March 2020 / Accepted: 1 April 2020 / Published: 2 April 2020
(This article belongs to the Special Issue Liposomes for Gene and Drug Delivery)
Neurofibromatosis type 1 (NF1) is an inherited neurological disorder. Approximately 5–13% of NF1 patients may develop a malignant peripheral nerve sheath tumor (MPNST), which is a neurofibrosarcoma transformed from the plexiform neurofibroma or schwannoma. Given the large size and easy metastasis of MPNST, it remains difficult to be cured by either surgical or conventional chemotherapy. In this study, we investigated the possibility of combining photodynamic therapy (PDT) and chemotherapy to treat MPNST by using a dual-effect liposome (named as PL-cDDP-Ce6), in which a chemotherapeutic agent, cisplatin (cDDP), and photosensitizer, chlorine e6 (Ce6) were encapsulated in the same carrier. The cytotoxic effect of PL-cDDP-Ce6 against MPNST cells was significantly higher than cells treated with liposomal cDDP or Ce6 alone or in combination after light irradiation. Treatment with the dual-effect liposomes in mice bearing xenograft MPNST tumor reveals a significant increase in survival rate compared to those treated with liposomal cDDP and Ce6 in combination. Moreover, there is no weight loss or derangements of serum biochemistry. In conclusion, this study demonstrates the clinical potential and advantage of using this liposomal drug for the treatment of MPNST. View Full-Text
Keywords: NF1; plexiform neurofibroma; MPNST; chemotherapy; liposome NF1; plexiform neurofibroma; MPNST; chemotherapy; liposome
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MDPI and ACS Style

Chen, C.-T.; Peng, P.-C.; Tsai, T.; Chien, H.-F.; Lee, M.-J. A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and Chemotherapy. Pharmaceutics 2020, 12, 317. https://doi.org/10.3390/pharmaceutics12040317

AMA Style

Chen C-T, Peng P-C, Tsai T, Chien H-F, Lee M-J. A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and Chemotherapy. Pharmaceutics. 2020; 12(4):317. https://doi.org/10.3390/pharmaceutics12040317

Chicago/Turabian Style

Chen, Chin-Tin, Po-Chun Peng, Tsuimin Tsai, Hsiung-Fei Chien, and Ming-Jen Lee. 2020. "A Novel Treatment Modality for Malignant Peripheral Nerve Sheath Tumor Using a Dual-Effect Liposome to Combine Photodynamic Therapy and Chemotherapy" Pharmaceutics 12, no. 4: 317. https://doi.org/10.3390/pharmaceutics12040317

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