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Review

Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers

1
Advanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania
2
Pediatric Department, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania
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Department of Internal Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania
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Department of Rheumatology and Physiotherapy, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania
5
NIRDBS—Institute of Biological Research Iasi, Department of Experimental and Applied Biology, 700107 Iasi, Romania
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(2), 171; https://doi.org/10.3390/pharmaceutics12020171
Received: 20 December 2019 / Revised: 10 February 2020 / Accepted: 15 February 2020 / Published: 18 February 2020
(This article belongs to the Special Issue Drug Delivery across Biological Barriers)
Viral infections are a major global health problem, representing a significant cause of mortality with an unfavorable continuously amplified socio-economic impact. The increased drug resistance and constant viral replication have been the trigger for important studies regarding the use of nanotechnology in antiviral therapies. Nanomaterials offer unique physico-chemical properties that have linked benefits for drug delivery as ideal tools for viral treatment. Currently, different types of nanomaterials namely nanoparticles, liposomes, nanospheres, nanogels, nanosuspensions and nanoemulsions were studied either in vitro or in vivo for drug delivery of antiviral agents with prospects to be translated in clinical practice. This review highlights the drug delivery nanosystems incorporating the major antiviral classes and their transport across specific barriers at cellular and intracellular level. Important reflections on nanomedicines currently approved or undergoing investigations for the treatment of viral infections are also discussed. Finally, the authors present an overview on the requirements for the design of antiviral nanotherapeutics. View Full-Text
Keywords: nanomaterials; antivirals; drug delivery; biological barriers nanomaterials; antivirals; drug delivery; biological barriers
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MDPI and ACS Style

Cojocaru, F.-D.; Botezat, D.; Gardikiotis, I.; Uritu, C.-M.; Dodi, G.; Trandafir, L.; Rezus, C.; Rezus, E.; Tamba, B.-I.; Mihai, C.-T. Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers. Pharmaceutics 2020, 12, 171. https://doi.org/10.3390/pharmaceutics12020171

AMA Style

Cojocaru F-D, Botezat D, Gardikiotis I, Uritu C-M, Dodi G, Trandafir L, Rezus C, Rezus E, Tamba B-I, Mihai C-T. Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers. Pharmaceutics. 2020; 12(2):171. https://doi.org/10.3390/pharmaceutics12020171

Chicago/Turabian Style

Cojocaru, Florina-Daniela, Doru Botezat, Ioannis Gardikiotis, Cristina-Mariana Uritu, Gianina Dodi, Laura Trandafir, Ciprian Rezus, Elena Rezus, Bogdan-Ionel Tamba, and Cosmin-Teodor Mihai. 2020. "Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers" Pharmaceutics 12, no. 2: 171. https://doi.org/10.3390/pharmaceutics12020171

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