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The Aerogen® Solo Is an Alternative to the Small Particle Aerosol Generator (SPAG-2) for Administration of Inhaled Ribavirin

1
Department of Infectious Diseases, St. Jude Children Research Hospital, Memphis, TN 38105, USA
2
Department of Critical Care and Pulmonary Medicine, St. Jude Children Research Hospital, Memphis, TN 38105, USA
3
Department of Pharmaceutical Sciences, St. Jude Children Research Hospital, Memphis, TN 38105, USA
4
Department of Pathology, St. Jude Children Research Hospital, Memphis, TN 38105, USA
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(12), 1163; https://doi.org/10.3390/pharmaceutics12121163
Received: 5 November 2020 / Revised: 24 November 2020 / Accepted: 26 November 2020 / Published: 29 November 2020
(This article belongs to the Special Issue Antiviral Drug Delivery)
Respiratory syncytial virus (RSV) is associated with adverse outcomes among immunocompromised patients. Inhaled ribavirin has been shown to improve mortality rates. The Small-Particle Aerosol Generator delivery system (SPAG-2) is the only FDA-cleared device to deliver inhaled ribavirin. However, it is difficult to set up and maintain. We developed a method for delivery of this medication using the vibrating mesh nebulizer (Aerogen®). We did not observe any adverse events with this method. View Full-Text
Keywords: RSV; ribavirin; Aerogen® Solo; SPAG-2; children; infection RSV; ribavirin; Aerogen® Solo; SPAG-2; children; infection
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MDPI and ACS Style

Dallas, R.H.; Rains, J.K.; Wilder, K.; Humphrey, W.; Cross, S.J.; Ghafoor, S.; Brazelton de Cardenas, J.N.; Hayden, R.T.; Hijano, D.R. The Aerogen® Solo Is an Alternative to the Small Particle Aerosol Generator (SPAG-2) for Administration of Inhaled Ribavirin. Pharmaceutics 2020, 12, 1163. https://doi.org/10.3390/pharmaceutics12121163

AMA Style

Dallas RH, Rains JK, Wilder K, Humphrey W, Cross SJ, Ghafoor S, Brazelton de Cardenas JN, Hayden RT, Hijano DR. The Aerogen® Solo Is an Alternative to the Small Particle Aerosol Generator (SPAG-2) for Administration of Inhaled Ribavirin. Pharmaceutics. 2020; 12(12):1163. https://doi.org/10.3390/pharmaceutics12121163

Chicago/Turabian Style

Dallas, Ronald H., Jason K. Rains, Keith Wilder, William Humphrey, Shane J. Cross, Saad Ghafoor, Jessica N. Brazelton de Cardenas, Randall T. Hayden, and Diego R. Hijano. 2020. "The Aerogen® Solo Is an Alternative to the Small Particle Aerosol Generator (SPAG-2) for Administration of Inhaled Ribavirin" Pharmaceutics 12, no. 12: 1163. https://doi.org/10.3390/pharmaceutics12121163

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