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Article

Electro-Hydrodynamic Drop-on-Demand Printing of Aqueous Suspensions of Drug Nanoparticles

Otto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA
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Pharmaceutics 2020, 12(11), 1034; https://doi.org/10.3390/pharmaceutics12111034
Received: 14 October 2020 / Revised: 24 October 2020 / Accepted: 27 October 2020 / Published: 29 October 2020
(This article belongs to the Special Issue Applications of Additive Manufacturing in Pharmaceutics)
We demonstrate the ability to fabricate dosage forms of a poorly water-soluble drug by using wet stirred media milling of a drug powder to produce an aqueous suspension of nanoparticles and then print it onto a porous biocompatible film. Contrary to conventional printing technologies, a deposited material is pulled out from the nozzle. This feature enables printing highly viscous materials with a precise control over the printed volume. Drug (griseofulvin) nanosuspensions prepared by wet media milling were printed onto porous hydroxypropyl methylcellulose films prepared by freeze-drying. The drug particles retained crystallinity and polymorphic form in the course of milling and printing. The versatility of this technique was demonstrated by printing the same amount of nanoparticles onto a film with droplets of different sizes. The mean drug content (0.19–3.80 mg) in the printed films was predicted by the number of droplets (5–100) and droplet volume (0.2–1.0 µL) (R2 = 0.9994, p-value < 10−4). Our results also suggest that for any targeted drug content, the number-volume of droplets could be modulated to achieve acceptable drug content uniformity. Analysis of the model-independent difference and similarity factors showed consistency of drug release profiles from films with a printed suspension. Zero-order kinetics described the griseofulvin release rate from 1.8% up to 82%. Overall, this study has successfully demonstrated that the electro-hydrodynamic drop-on-demand printing of an aqueous drug nanosuspension enables accurate and controllable drug dosing in porous polymer films, which exhibited acceptable content uniformity and reproducible drug release. View Full-Text
Keywords: precision dosage form; drop-on-demand printing; poorly water-soluble drugs; nanoparticles; biocompatible films; drug release profile precision dosage form; drop-on-demand printing; poorly water-soluble drugs; nanoparticles; biocompatible films; drug release profile
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MDPI and ACS Style

Elele, E.; Shen, Y.; Boppana, R.; Afolabi, A.; Bilgili, E.; Khusid, B. Electro-Hydrodynamic Drop-on-Demand Printing of Aqueous Suspensions of Drug Nanoparticles. Pharmaceutics 2020, 12, 1034. https://doi.org/10.3390/pharmaceutics12111034

AMA Style

Elele E, Shen Y, Boppana R, Afolabi A, Bilgili E, Khusid B. Electro-Hydrodynamic Drop-on-Demand Printing of Aqueous Suspensions of Drug Nanoparticles. Pharmaceutics. 2020; 12(11):1034. https://doi.org/10.3390/pharmaceutics12111034

Chicago/Turabian Style

Elele, Ezinwa, Yueyang Shen, Rajyalakshmi Boppana, Afolawemi Afolabi, Ecevit Bilgili, and Boris Khusid. 2020. "Electro-Hydrodynamic Drop-on-Demand Printing of Aqueous Suspensions of Drug Nanoparticles" Pharmaceutics 12, no. 11: 1034. https://doi.org/10.3390/pharmaceutics12111034

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