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Open AccessReview

Drug Delivery Systems for Vitamin D Supplementation and Therapy

Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(7), 347;
Received: 13 June 2019 / Revised: 11 July 2019 / Accepted: 16 July 2019 / Published: 18 July 2019
PDF [1483 KB, uploaded 18 July 2019]


Vitamin D (VD) is a fat-soluble prohormone well known for its role in regulating calcium and phosphate metabolism. It has been clinically used for many years to prevent rickets in children, osteomalacia, and osteoporosis in adults. VD insufficiency is a common medical condition, and many supplements are available in the market in order to increase serum 25-hydroxy VD levels to recommended amounts. Over the course of the last decades, it has become increasingly clear that calcitriol, an active form of VD, regulates multiple cellular processes with effects on normal and malignant cell growth and differentiation, and on the immune and cardiovascular function. Increasing evidence supports the role of the VD system in cancer prevention and therapy. Due to many pleiotropic and beneficial effects in extra-skeletal disorders, VD has gained potential and become an interesting active for encapsulation into drug delivery systems. The purpose of this review is to present the diversity of drug delivery systems that have been reported for VD or VD derivatives in an orderly manner across the following categories: Oral administration, application on the skin, cancer prevention/therapy, and other diseases or routes of administration. View Full-Text
Keywords: vitamin D; cholecalciferol; drug delivery systems; targeted delivery; nanoparticles; food fortification; cancer vitamin D; cholecalciferol; drug delivery systems; targeted delivery; nanoparticles; food fortification; cancer

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Glowka, E.; Stasiak, J.; Lulek, J. Drug Delivery Systems for Vitamin D Supplementation and Therapy. Pharmaceutics 2019, 11, 347.

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