Next Article in Journal
Transmucosal Absorption Enhancers in the Drug Delivery Field
Next Article in Special Issue
Hydrodynamics of Intravitreal Injections into Liquid Vitreous Substitutes
Previous Article in Journal
Ionic Polymethacrylate Based Delivery Systems: Effect of Carrier Topology and Drug Loading
Previous Article in Special Issue
Biomedical Applications of Hyaluronic Acid-Based Nanomaterials in Hyperthermic Cancer Therapy
Open AccessReview

Design of Soft Nanocarriers Combining Hyaluronic Acid with Another Functional Polymer for Cancer Therapy and Other Biomedical Applications

Grenoble Alpes University, Centre de Recherches sur les Macromolécules Végétales (CERMAV)-CNRS, 601, rue de la Chimie, BP 53, CEDEX 9, 38041 Grenoble, France
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(7), 338;
Received: 2 June 2019 / Revised: 9 July 2019 / Accepted: 11 July 2019 / Published: 15 July 2019
(This article belongs to the Special Issue Hyaluronic Acid for Biomedical Applications)
PDF [9872 KB, uploaded 15 July 2019]


The rapid advancement in medicine requires the search for new drugs, but also for new carrier systems for more efficient and targeted delivery of the bioactive molecules. Among the latter, polymeric nanocarriers have an increasingly growing potential for clinical applications due to their unique physical and chemical characteristics. In this regard, nanosystems based on hyaluronic acid (HA), a polysaccharide which is ubiquitous in the body, have attracted particular interest because of the biocompatibility, biodegradability and nonimmunogenic property provided by HA. Furthermore, the fact that hyaluronic acid can be recognized by cell surface receptors in tumor cells, makes it an ideal candidate for the targeted delivery of anticancer drugs. In this review, we compile a comprehensive overview of the different types of soft nanocarriers based on HA conjugated or complexed with another polymer: micelles, nanoparticles, nanogels and polymersomes. Emphasis is made on the properties of the polymers used as well as the synthetic approaches for obtaining the different HA-polymer systems. Fabrication, characterization and potential biomedical applications of the nanocarriers will also be described. View Full-Text
Keywords: hyaluronic acid; polymeric nanocarriers; drug delivery hyaluronic acid; polymeric nanocarriers; drug delivery

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Rippe, M.; Cosenza, V.; Auzély-Velty, R. Design of Soft Nanocarriers Combining Hyaluronic Acid with Another Functional Polymer for Cancer Therapy and Other Biomedical Applications. Pharmaceutics 2019, 11, 338.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top