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Design of Soft Nanocarriers Combining Hyaluronic Acid with Another Functional Polymer for Cancer Therapy and Other Biomedical Applications

Grenoble Alpes University, Centre de Recherches sur les Macromolécules Végétales (CERMAV)-CNRS, 601, rue de la Chimie, BP 53, CEDEX 9, 38041 Grenoble, France
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(7), 338;
Received: 2 June 2019 / Revised: 9 July 2019 / Accepted: 11 July 2019 / Published: 15 July 2019
(This article belongs to the Special Issue Hyaluronic Acid for Biomedical Applications)
The rapid advancement in medicine requires the search for new drugs, but also for new carrier systems for more efficient and targeted delivery of the bioactive molecules. Among the latter, polymeric nanocarriers have an increasingly growing potential for clinical applications due to their unique physical and chemical characteristics. In this regard, nanosystems based on hyaluronic acid (HA), a polysaccharide which is ubiquitous in the body, have attracted particular interest because of the biocompatibility, biodegradability and nonimmunogenic property provided by HA. Furthermore, the fact that hyaluronic acid can be recognized by cell surface receptors in tumor cells, makes it an ideal candidate for the targeted delivery of anticancer drugs. In this review, we compile a comprehensive overview of the different types of soft nanocarriers based on HA conjugated or complexed with another polymer: micelles, nanoparticles, nanogels and polymersomes. Emphasis is made on the properties of the polymers used as well as the synthetic approaches for obtaining the different HA-polymer systems. Fabrication, characterization and potential biomedical applications of the nanocarriers will also be described. View Full-Text
Keywords: hyaluronic acid; polymeric nanocarriers; drug delivery hyaluronic acid; polymeric nanocarriers; drug delivery
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Rippe, M.; Cosenza, V.; Auzély-Velty, R. Design of Soft Nanocarriers Combining Hyaluronic Acid with Another Functional Polymer for Cancer Therapy and Other Biomedical Applications. Pharmaceutics 2019, 11, 338.

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