Next Article in Journal
Delivery of Niacinamide to the Skin Using Microneedle-Like Particles
Previous Article in Journal
Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled in Silico-Experimental Studies. Part II: Self-Assembled siRNA Nanocarriers
Article Menu

Export Article

Open AccessReview

Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs

1
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam
2
Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam
3
School of Medicine, Deakin University, Geelong 3216, Australia
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(7), 325; https://doi.org/10.3390/pharmaceutics11070325
Received: 7 March 2019 / Revised: 25 April 2019 / Accepted: 10 May 2019 / Published: 10 July 2019
  |  
PDF [3298 KB, uploaded 12 July 2019]
  |  

Abstract

Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of poorly water-soluble molecules for future application in the therapy of numerous diseases. The context of current studies will give readers an overview of the conjugation strategies for fabricating nanoparticles, which have expanded from conjugated materials to the surface conjugation of nanovehicles. Moreover, nanoconjugates for theranostics are also discussed and highlighted. Overall, these state-of-the-art conjugation methods and these techniques and applications for nanoparticulate systems of poorly water-soluble drugs will inspire scientists to explore and discover more productive techniques and methodologies for drug development. View Full-Text
Keywords: nanoconjugate; nanotechnology; poorly water-soluble drugs; theranostic; drug delivery; biomedical applications nanoconjugate; nanotechnology; poorly water-soluble drugs; theranostic; drug delivery; biomedical applications
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Tran, T.T.D.; Tran, P.H.L. Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs. Pharmaceutics 2019, 11, 325.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top