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Open AccessArticle

Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin

1
Medical Biology Centre, School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
2
School of Pharmacy, University of Jordan, Amman 11942, Jordan
3
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Aleppo University, P.O. Box 12212, Aleppo, Syria
4
Department of Pharmaceutics, Faculty of Pharmacy, Hasanuddin University, Makassar 90234, Indonesia
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(7), 308; https://doi.org/10.3390/pharmaceutics11070308
Received: 6 May 2019 / Revised: 17 June 2019 / Accepted: 24 June 2019 / Published: 2 July 2019
(This article belongs to the Special Issue Drug Delivery Systems Using Various Microneedle Technologies)
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Abstract

The objective of this study was to evaluate the intradermal delivery of curcumin utilising poly(vinylalcohol) (PVA)-based microneedles loaded with curcumin nanosuspension (CU-NS). Nanoprecipitation was used to formulate the CU-NS which was then incorporated into PVA microneedles arrays consisting of 11 × 11 microneedles of conical shape, measuring 900 µm in height and with 300 µm base diameter. The nanosuspension particle size was 520 ± 40 nm, with a polydispersity of 0.27 ± 0.02 using sodium lauryl sulfate (SLS) as a stabiliser. In vitro dissolution studies in 10% w/v Tween 80 showed that the CU-NS dissolved significantly faster than unmodified curcumin powder, with 34% released from the CU-NS, compared to 16% from the curcumin powder after 48 h. The CU-NS-loaded microneedles (CU-MN) were able to withstand a compression force of 32 N for 30 s. Moreover, these microneedles were able to penetrate excised neonatal porcine skin to a depth of 500 µm, dissolved completely in the skin within 60 min. After CU-MN dissolution, the drug diffused from the application site and migrated through the skin layers down to 2300 µm, significantly more than observed with topical application of CU-NS. This suggest that the fabricated microneedles with the incorporated CU-NS could enhance the intradermal delivery of curcumin. View Full-Text
Keywords: curcumin; dissolving microneedles; intradermal; poly(vinylalcohol); nanosuspension curcumin; dissolving microneedles; intradermal; poly(vinylalcohol); nanosuspension
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Abdelghany, S.; Tekko, I.A.; Vora, L.; Larrañeta, E.; Permana, A.D.; Donnelly, R.F. Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin. Pharmaceutics 2019, 11, 308.

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