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Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy

Department of Chemistry, American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo 11835, Egypt
Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany
Authors to whom correspondence should be addressed.
Pharmaceutics 2019, 11(6), 292;
Received: 17 May 2019 / Revised: 15 June 2019 / Accepted: 19 June 2019 / Published: 20 June 2019
PDF [1223 KB, uploaded 22 June 2019]


Chemotherapeutic agents are considered one of the strategies in treating cancer. However, their use is faced by many challenges, such as poor water solubility leading to poor bioavailability and non-selective targeting of cancerous cells leading to diminished therapeutic actions and systemic adverse effects. Many approaches were adopted to overcome these drawbacks and to achieve the targeted delivery of the chemotherapeutic agents to the cancerous cells while minimizing adverse effects. Recently, supramolecular systems such as macrocycles have gained attention in the field of cancer therapy for being able to encapsulate different anticancer drugs via either host-guest complexation or self-assembly leading to a myriad of advantages. This review highlights the most recent studies concerned with the design of such novel systems for cancer therapy. View Full-Text
Keywords: chemotherapy; supermolecular; anticancer drugs; macrocycles chemotherapy; supermolecular; anticancer drugs; macrocycles

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Fahmy, S.A.; Brüßler, J.; Alawak, M.; El-Sayed, M.M.H.; Bakowsky, U.; Shoeib, T. Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy. Pharmaceutics 2019, 11, 292.

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