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Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice

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Department of Medical Engineering, Dongguk University College of Medicine, Goyang-si, Gyeonggi-do 10326, Korea
2
Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi-do 10326, Korea
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Department of Clinical Pharmacology and Therapeutics, Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi-do 10326, Korea
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Department of Biostatistics, Dongguk University College of Medicine, Goyang-si, Gyeonggi-do 10326, Korea
5
Department of Electrical Biological Physics and Institute of Biomaterials, Kwangwoon University, Seoul 01897, Korea
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2019, 11(4), 192; https://doi.org/10.3390/pharmaceutics11040192
Received: 12 February 2019 / Revised: 11 April 2019 / Accepted: 17 April 2019 / Published: 19 April 2019
Recent reports using a breathing simulator system have suggested that mesh nebulizers provide more effective medication delivery than jet nebulizers. In this study, the performances of jet and mesh nebulizers were evaluated by comparing their aerosol drug delivery efficiencies in mice. We compared four home nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U22), and a vibrating mesh nebulizer (NE-SM1). After mice were exposed to salbutamol aerosol, the levels of salbutamol in serum and lung were estimated by enzyme linked immunoassay (ELISA). The residual volume of salbutamol was the largest at 34.6% in PARI BOY SX, while the values for NE-U22 and NE-SM1 mesh nebulizers were each less than 1%. The salbutamol delivery efficiencies of NE-U22 and NE-SM1 were higher than that of PARI BOY SX, as the total delivered amounts of lung and serum were 39.9% and 141.7% as compared to PARI BOY SX, respectively. The delivery efficiency of the mesh nebulizer was better than that of the jet nebulizer. Although the jet nebulizer can generate smaller aerosol particles than the mesh nebulizer used in this study, the output rate of the jet nebulizer is low, resulting in lower salbutamol delivery efficiency. Therefore, clinical validation of the drug delivery efficiency according to nebulizer type is necessary to avoid overdose and reduced drug wastage. View Full-Text
Keywords: nebulizer; drug delivery efficiency; salbutamol; aerosol size; residual volume nebulizer; drug delivery efficiency; salbutamol; aerosol size; residual volume
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Chang, K.H.; Moon, S.-H.; Oh, J.Y.; Yoon, Y.-S.; Gu, N.; Lim, C.-Y.; Park, B.J.; Nam, K.C. Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice. Pharmaceutics 2019, 11, 192.

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