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Article

Combination of Zinc Hyaluronate and Metronidazole in a Lipid-Based Drug Delivery System for the Treatment of Periodontitis

1
Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Szeged 6720, Hungary
2
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged 6720, Hungary
3
Department of Periodontology, Faculty of Dentistry, University of Szeged, Szeged 6720, Hungary
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(3), 142; https://doi.org/10.3390/pharmaceutics11030142
Received: 11 February 2019 / Revised: 18 March 2019 / Accepted: 21 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Hyaluronic Acid for Biomedical Applications)
Background: Despite being a highly prevalent disease and a possible contributor to adult tooth loss, periodontitis possesses no well-established therapy. The aim of the recent study was the development and evaluation of a mucoadhesive monophase lipid formulation for the sustained local delivery of amoxicillin, metronidazole, and/or zinc hyaluronate or gluconate. Methods: To investigate our formulations, differential scanning calorimetry, X-ray diffraction, swelling, erosion, mucoadhesivity, drug release, and antimicrobial measurements were performed. Results: Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) results show that the loaded drugs are in a suspended form, the softening of the formulations starts at body temperature, but a part remains solid, providing sustained release. Swelling of the lipid compositions is affected by the hydrophilic components, their concentration, and the strength of the coherent lipid structure, while their erosion is impacted by the emulsification of melted lipid components. Conclusions: Results of drug release and antimicrobial effectiveness measurements show that a sustained release may be obtained. Amoxicillin had higher effectiveness against oral pathogens than metronidazole or zinc hyaluronate alone, but the combination of the two latter could provide similar effectiveness to amoxicillin. The applied mucoadhesive polymer may affect adhesivity, drug release through the swelling mechanism, and antimicrobial effect as well. View Full-Text
Keywords: periodontitis; lipid drug delivery; zinc hyaluronate; amoxicillin; metronidazole periodontitis; lipid drug delivery; zinc hyaluronate; amoxicillin; metronidazole
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MDPI and ACS Style

Léber, A.; Budai-Szűcs, M.; Urbán, E.; Vályi, P.; Gácsi, A.; Berkó, S.; Kovács, A.; Csányi, E. Combination of Zinc Hyaluronate and Metronidazole in a Lipid-Based Drug Delivery System for the Treatment of Periodontitis. Pharmaceutics 2019, 11, 142. https://doi.org/10.3390/pharmaceutics11030142

AMA Style

Léber A, Budai-Szűcs M, Urbán E, Vályi P, Gácsi A, Berkó S, Kovács A, Csányi E. Combination of Zinc Hyaluronate and Metronidazole in a Lipid-Based Drug Delivery System for the Treatment of Periodontitis. Pharmaceutics. 2019; 11(3):142. https://doi.org/10.3390/pharmaceutics11030142

Chicago/Turabian Style

Léber, Attila, Mária Budai-Szűcs, Edit Urbán, Péter Vályi, Attila Gácsi, Szilvia Berkó, Anita Kovács, and Erzsébet Csányi. 2019. "Combination of Zinc Hyaluronate and Metronidazole in a Lipid-Based Drug Delivery System for the Treatment of Periodontitis" Pharmaceutics 11, no. 3: 142. https://doi.org/10.3390/pharmaceutics11030142

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