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Article

In Vitro Enhanced Skin Permeation and Retention of Imiquimod Loaded in β-Cyclodextrin Nanosponge Hydrogel

1
Department of Drug Science and Technology, University of Turin, via P. Giuria 9, 10125 Turin, Italy
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Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, H-4033 Debrecen, Hungary
3
Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, 13344 Marseille, France
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Department of Chemistry, University of Turin, via Giuria 7, 10125 Turin, Italy
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Dipartimento di Scienze della Sanità Pubblica e Pediatriche, University of Turin, 10126 Turin, Italy
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Dipartimento di Chirurgia Generale e Specialistiche, Banca della Cute, AOU Città della Salute e della Scienza di Torino, 10126 Turin, Italy
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(3), 138; https://doi.org/10.3390/pharmaceutics11030138
Received: 15 February 2019 / Revised: 8 March 2019 / Accepted: 13 March 2019 / Published: 20 March 2019
(This article belongs to the Special Issue Cyclodextrins in Drug Formulation and Delivery)
Imiquimod (IMQ) is an immune response modifier clinically used for the treatment of various topical diseases. However, its poor aqueous solubility and skin penetration capability make the topical delivery of IMQ a challenging task. This work aims at developing a nanomedicine-based topical formulation, carrying IMQ to control the scarring process for the treatment of aberrant wounds. For this purpose, IMQ was loaded in β-cyclodextrin-based nanosponges and dispersed in a hydrogel suitable for dermal application. The formulation was characterized in vitro and compared with IMQ inclusion complexes, with (2-hydroxy)propyl β-cyclodextrin(HPβCD) and carboxymethyl β-cyclodextrin (CMβCD) showing enhanced penetration properties. The hydrogel containing IMQ-loaded nanosponges could act as a drug reservoir and guarantee the sustained release of IMQ through the skin. A greater inhibitory effect on fibroblast proliferation was observed for IMQ loaded in nanosponges compared to the other formulations. View Full-Text
Keywords: cyclodextrins; inclusion complex; nanosponges; controlled release; imiquimod cyclodextrins; inclusion complex; nanosponges; controlled release; imiquimod
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MDPI and ACS Style

Argenziano, M.; Haimhoffer, A.; Bastiancich, C.; Jicsinszky, L.; Caldera, F.; Trotta, F.; Scutera, S.; Alotto, D.; Fumagalli, M.; Musso, T.; Castagnoli, C.; Cavalli, R. In Vitro Enhanced Skin Permeation and Retention of Imiquimod Loaded in β-Cyclodextrin Nanosponge Hydrogel. Pharmaceutics 2019, 11, 138. https://doi.org/10.3390/pharmaceutics11030138

AMA Style

Argenziano M, Haimhoffer A, Bastiancich C, Jicsinszky L, Caldera F, Trotta F, Scutera S, Alotto D, Fumagalli M, Musso T, Castagnoli C, Cavalli R. In Vitro Enhanced Skin Permeation and Retention of Imiquimod Loaded in β-Cyclodextrin Nanosponge Hydrogel. Pharmaceutics. 2019; 11(3):138. https://doi.org/10.3390/pharmaceutics11030138

Chicago/Turabian Style

Argenziano, Monica, Adam Haimhoffer, Chiara Bastiancich, László Jicsinszky, Fabrizio Caldera, Francesco Trotta, Sara Scutera, Daniela Alotto, Mara Fumagalli, Tiziana Musso, Carlotta Castagnoli, and Roberta Cavalli. 2019. "In Vitro Enhanced Skin Permeation and Retention of Imiquimod Loaded in β-Cyclodextrin Nanosponge Hydrogel" Pharmaceutics 11, no. 3: 138. https://doi.org/10.3390/pharmaceutics11030138

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