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What Drives Innovation: The Canadian Touch on Liposomal Therapeutics
Open AccessReview

Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy

by Courtney van Ballegooie 1,2, Alice Man 3,†, Mi Win 4,† and Donald T. Yapp 1,3,*
1
Experimental Therapeutics, BC Cancer, Vancouver, BC V5Z 1L3, Canada
2
Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
3
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
4
Department of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2019, 11(3), 125; https://doi.org/10.3390/pharmaceutics11030125
Received: 26 February 2019 / Revised: 12 March 2019 / Accepted: 13 March 2019 / Published: 16 March 2019
(This article belongs to the Special Issue Drug Delivery Technology Development in Canada)
This review explores the use of energy sources, including ultrasound, magnetic fields, and external beam radiation, to trigger the delivery of drugs from liposomes in a tumor in a spatially-specific manner. Each section explores the mechanism(s) of drug release that can be achieved using liposomes in conjunction with the external trigger. Subsequently, the treatment’s formulation factors are discussed, highlighting the parameters of both the therapy and the medical device. Additionally, the pre-clinical and clinical trials of each triggered release method are explored. Lastly, the advantages and disadvantages, as well as the feasibility and future outlook of each triggered release method, are discussed. View Full-Text
Keywords: triggered drug release; liposomes; ultrasound; magnetic fields; radiation triggered drug release; liposomes; ultrasound; magnetic fields; radiation
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van Ballegooie, C.; Man, A.; Win, M.; Yapp, D.T. Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy. Pharmaceutics 2019, 11, 125.

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