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Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 1H9, Canada
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Pharmaceutics 2019, 11(3), 129; https://doi.org/10.3390/pharmaceutics11030129
Received: 6 February 2019 / Revised: 9 March 2019 / Accepted: 14 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Drug Delivery Technology Development in Canada)
Routes of drug administration and the corresponding physicochemical characteristics of a given route play significant roles in therapeutic efficacy and short term/long term biological effects. Each delivery method has favorable aspects and limitations, each requiring a specific delivery vehicles design. Among various routes, oral delivery has been recognized as the most attractive method, mainly due to its potential for solid formulations with long shelf life, sustained delivery, ease of administration and intensified immune response. At the same time, a few challenges exist in oral delivery, which have been the main research focus in the field in the past few years. The present work concisely reviews different administration routes as well as the advantages and disadvantages of each method, highlighting why oral delivery is currently the most promising approach. Subsequently, the present work discusses the main obstacles for oral systems and explains the most recent solutions proposed to deal with each issue. View Full-Text
Keywords: oral delivery; biological barriers; co-delivery; throughput; sustained delivery oral delivery; biological barriers; co-delivery; throughput; sustained delivery
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Homayun, B.; Lin, X.; Choi, H.-J. Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals. Pharmaceutics 2019, 11, 129.

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