Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment
Abstract
:1. Introduction
2. Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment
3. Recent Trends of Stimuli-Responsive Dendrimers in Controlling the Release of Drug at Target Sites
3.1. Functionalized Dendrimer with Polymers and Targeting Agents
3.2. Internal-Stimuli-Responsive Dendrimers
3.2.1. Redox-Sensitive Dendrimers
3.2.2. pH-Sensitive Dendrimers
3.2.3. Thermo-Sensitive Dendrimers
3.3. External-Stimuli-Responsive Dendrimers
3.3.1. UV Light-Sensitive Dendrimers
3.3.2. Ultrasound-Sensitive Dendrimers
3.3.3. Magnetic-Sensitive Dendrimers
3.3.4. Enzyme-Sensitive Dendrimers
4. Current Advances in General Biomedical Applications of Multi-Stimuli-Responsive Dendrimers
4.1. Drug Delivery
4.2. Diagnostics
4.3. Tissue Regeneration
5. Conclusion and Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Polymer | Generation | Modification | Responsiveness | Payload | Ref. |
---|---|---|---|---|---|
PAMAM | G4 | PEG | Redox and pH | Doxorubicin | [31] |
PAMAM | G3.5 | Heparin | Redox and pH | Letrozole | [32] |
PAMAM | G4 | PEG | Redox | Doxorubicin | [33] |
PBAE | G4 | 2-(N,N-dimethylamino)ethyl acrylate | pH and temperature | Doxorubicin | [34] |
PAMAM | G4 | PEG-chitosan-folic acid | pH | pDNA | [35] |
Stimuli | Responsive moiety | Ref. | |
---|---|---|---|
Internal stimuli | Reduction | Au−S | [74] |
Disulfide | [75,76] | ||
pH | 3,4,5,6-tetrahydrophthalic anhydride | [77] | |
Hydrazine | [34,68,78] | ||
Temperature | Poly (NiPAM) | [79,80,81] | |
Isobutyramide (IBAM) | [82] | ||
4-(isopropylamino)-4-oxobutanoic acid (IPAOBA) and 4-(diethylamino)-4-oxobutanoic acid (DEAOBA) | [83] | ||
External stimuli | Light | Ortho-nitrobenzyl (ONB) | [51,84,85,86] |
4-(3-(trifluoromethyl)-3H-diazirin-3-yl) benzyl bromide | [87] | ||
Aso-nitrobenzyl and diazobenzene | [88] | ||
Ultrasound | Sonophoresis | [89,90,91,92,93,94] | |
Magnetic field | Fe3O4@SiO2-NH2 | [95] | |
Enzyme | Gly-Phe-Leu-Gly (GFLG) | [96] | |
Lysine | [97] |
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Le, N.T.T.; Nguyen, T.N.Q.; Cao, V.D.; Hoang, D.T.; Ngo, V.C.; Hoang Thi, T.T. Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment. Pharmaceutics 2019, 11, 591. https://doi.org/10.3390/pharmaceutics11110591
Le NTT, Nguyen TNQ, Cao VD, Hoang DT, Ngo VC, Hoang Thi TT. Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment. Pharmaceutics. 2019; 11(11):591. https://doi.org/10.3390/pharmaceutics11110591
Chicago/Turabian StyleLe, Ngoc Thuy Trang, Thi Nhu Quynh Nguyen, Van Du Cao, Duc Thuan Hoang, Van Cuong Ngo, and Thai Thanh Hoang Thi. 2019. "Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment" Pharmaceutics 11, no. 11: 591. https://doi.org/10.3390/pharmaceutics11110591