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Article

Hyperthermia-Triggered Doxorubicin Release from Polymer-Coated Magnetic Nanorods

Department of Applied Physics, School of Sciences, University of Granada, 18071 Granada, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2019, 11(10), 517; https://doi.org/10.3390/pharmaceutics11100517
Received: 19 August 2019 / Revised: 24 September 2019 / Accepted: 1 October 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Triggered Drug Delivery Systems)
In this paper, it is proposed that polymer-coated magnetic nanorods (MNRs) can be used with the advantage of a double objective: first, to serve as magnetic hyperthermia agents, and second, to be used as magnetic vehicles for the antitumor drug doxorubicin (DOX). Two different synthetic methodologies (hydrothermal and co-precipitation) were used to obtain MNRs of maghemite and magnetite. They were coated with poly(ethyleneimine) and poly(sodium 4-styrenesulfonate), and loaded with DOX, using the Layer-by-Layer technique. Evidence of the polymer coating and the drug loading was justified by ATR-FTIR and electrophoretic mobility measurements, and the composition of the coated nanorods was obtained by a thermogravimetric analysis. The nanorods were tested as magnetic hyperthermia agents, and it was found that they provided sufficiently large heating rates to be used as adjuvant therapy against solid tumors. DOX loading and release were determined by UV-visible spectroscopy, and it was found that up to 50% of the loaded drug was released in about 5 h, although the rate of release could be regulated by simultaneous application of hyperthermia, which acts as a sort of external release-trigger. Shape control offers another physical property of the particles as candidates to interact with tumor cells, and particles that are not too elongated can easily find their way through the cell membrane. View Full-Text
Keywords: magnetic nanorod; biocompatible polymer; drug delivery system; doxorubicin; magnetic hyperthermia magnetic nanorod; biocompatible polymer; drug delivery system; doxorubicin; magnetic hyperthermia
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MDPI and ACS Style

Reyes-Ortega, F.; Checa Fernández, B.L.; Delgado, A.V.; Iglesias, G.R. Hyperthermia-Triggered Doxorubicin Release from Polymer-Coated Magnetic Nanorods. Pharmaceutics 2019, 11, 517. https://doi.org/10.3390/pharmaceutics11100517

AMA Style

Reyes-Ortega F, Checa Fernández BL, Delgado AV, Iglesias GR. Hyperthermia-Triggered Doxorubicin Release from Polymer-Coated Magnetic Nanorods. Pharmaceutics. 2019; 11(10):517. https://doi.org/10.3390/pharmaceutics11100517

Chicago/Turabian Style

Reyes-Ortega, Felisa, Blanca L. Checa Fernández, Angel V. Delgado, and Guillermo R. Iglesias 2019. "Hyperthermia-Triggered Doxorubicin Release from Polymer-Coated Magnetic Nanorods" Pharmaceutics 11, no. 10: 517. https://doi.org/10.3390/pharmaceutics11100517

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