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Open AccessArticle

Comparative Evaluation of Solubility, Cytotoxicity and Photostability Studies of Resveratrol and Oxyresveratrol Loaded Nanosponges

1
Department of Chemistry, University of Torino, via P. Giuria 7, 10125 Torino, Italy
2
Department of Biochemistry and Molecular Biology-A, Faculty of Biology, 13 University of Murcia - Regional Campus of International Excellence “Campus Mare 14 Nostrum”, E-30100 Murcia, Spain
3
Department of Drug Science and Technology, University of Torino, via P. Giuria 9, 10125 Torino, Italy
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(10), 545; https://doi.org/10.3390/pharmaceutics11100545
Received: 16 September 2019 / Revised: 17 October 2019 / Accepted: 18 October 2019 / Published: 20 October 2019
(This article belongs to the Special Issue Cyclodextrin-Based Drug Delivery System)
Resveratrol and oxyresveratrol are natural polyphenolic stilbenes with several important pharmacological activities. However, low solubility and aqueous instability are the major limitations in their drug delivery applications. In the present work, we demonstrated the encapsulation of resveratrol and oxyresveratrol with nanosponge to improve solubility and stability. Several characterization techniques were used to confirm the encapsulation of both drug molecules within the nanosponges. The high encapsulation efficiency of resveratrol (77.73%) and oxyresveratrol (80.33%) was achieved within the nanosponges. Transmission electron microscopy suggested uniform spherical size particles of resveratrol and oxyresveratrol loaded nanosponges. Compared to free drugs, better protection against UV degradation was observed for resveratrol-loaded nanosponge (2-fold) and oxyresveratrol-loaded nanosponge (3-fold). Moreover, a higher solubilization of resveratrol- and oxyresveratrol-loaded nanosponges lead to a better antioxidant activity compared to drug molecules alone. Cytotoxicity studies against DU-145 prostate cancer cell lines further suggested improved activity of both resveratrol and oxyresveratrol-loaded nanosponges without any significant toxicity of blank nanosponges. View Full-Text
Keywords: resveratrol; oxyresveratrol; β-cyclodextrin; nanosponges; solubility enhancement; drug-delivery; cytotoxicity; stability studies resveratrol; oxyresveratrol; β-cyclodextrin; nanosponges; solubility enhancement; drug-delivery; cytotoxicity; stability studies
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Dhakar, N.K.; Matencio, A.; Caldera, F.; Argenziano, M.; Cavalli, R.; Dianzani, C.; Zanetti, M.; López-Nicolás, J.M.; Trotta, F. Comparative Evaluation of Solubility, Cytotoxicity and Photostability Studies of Resveratrol and Oxyresveratrol Loaded Nanosponges. Pharmaceutics 2019, 11, 545.

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