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Pharmaceutics
Volume 10
Issue 4
10.3390/pharmaceutics10040277
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Review

Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles

by
Matteo Briguglio
1,*,
Silvana Hrelia
2,
Marco Malaguti
2,
Loredana Serpe
3,
Roberto Canaparo
3,
Bernardo Dell’Osso
4,5,6,
Roberta Galentino
7,
Sara De Michele
7,
Carlotta Zanaboni Dina
7,
Mauro Porta
7 and
Giuseppe Banfi
1,8
1
IRCCS Orthopedic Institute Galeazzi, Scientific Direction, 20161 Milan, Italy
2
Department of Life Quality Studies, University of Bologna, 47921 Rimini, Italy
3
Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy
4
Department of Biomedical and Clinical Sciences Luigi Sacco, Department of Psychiatry, ASST Fatebenefratelli-Sacco, University of Milan, 20157 Milan, Italy
5
“Aldo Ravelli” Center for Neurotechnology and Brain Therapeutic, University of Milan, 20142 Milan, Italy
6
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305-5717, USA
7
IRCCS Orthopedic Institute Galeazzi, Tourette’s Syndrome and Movement Disorders Centre, 20161 Milan, Italy
8
Faculty of Medicine and Surgery, University Vita e Salute San Raffaele, 20132 Milan, Italy
*
Author to whom correspondence should be addressed.
Pharmaceutics 2018, 10(4), 277; https://doi.org/10.3390/pharmaceutics10040277
Submission received: 10 November 2018 / Revised: 29 November 2018 / Accepted: 13 December 2018 / Published: 14 December 2018
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Abstract

Preclinical and clinical studies suggest that many food molecules could interact with drug transporters and metabolizing enzymes through different mechanisms, which are predictive of what would be observed clinically. Given the recent incorporation of dietary modifications or supplements in traditional medicine, an increase in potential food-drug interactions has also appeared. The objective of this article is to review data regarding the influence of food on drug efficacy. Data from Google Scholar, PubMed, and Scopus databases was reviewed for publications on pharmaceutical, pharmacokinetic, and pharmacodynamic mechanisms. The following online resources were used to integrate functional and bioinformatic results: FooDB, Phenol-Explorer, Dr. Duke's Phytochemical and Ethnobotanical Databases, DrugBank, UniProt, and IUPHAR/BPS Guide to Pharmacology. A wide range of food compounds were shown to interact with proteins involved in drug pharmacokinetic/pharmacodynamic profiles, starting from drug oral bioavailability to enteric/hepatic transport and metabolism, blood transport, and systemic transport/metabolism. Knowledge of any food components that may interfere with drug efficacy is essential, and would provide a link for obtaining a holistic view for cancer, cardiovascular, musculoskeletal, or neurological therapies. However, preclinical interaction may be irrelevant to clinical interaction, and health professionals should be aware of the limitations if they intend to optimize the therapeutic effects of drugs.
Keywords: food-drug interactions; herb-drug interactions; pharmacologic processes; dietary supplements; nutraceutical; precision medicine food-drug interactions; herb-drug interactions; pharmacologic processes; dietary supplements; nutraceutical; precision medicine

Share and Cite

MDPI and ACS Style

Briguglio, M.; Hrelia, S.; Malaguti, M.; Serpe, L.; Canaparo, R.; Dell’Osso, B.; Galentino, R.; De Michele, S.; Zanaboni Dina, C.; Porta, M.; et al. Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles. Pharmaceutics 2018, 10, 277. https://doi.org/10.3390/pharmaceutics10040277

AMA Style

Briguglio M, Hrelia S, Malaguti M, Serpe L, Canaparo R, Dell’Osso B, Galentino R, De Michele S, Zanaboni Dina C, Porta M, et al. Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles. Pharmaceutics. 2018; 10(4):277. https://doi.org/10.3390/pharmaceutics10040277

Chicago/Turabian Style

Briguglio, Matteo, Silvana Hrelia, Marco Malaguti, Loredana Serpe, Roberto Canaparo, Bernardo Dell’Osso, Roberta Galentino, Sara De Michele, Carlotta Zanaboni Dina, Mauro Porta, and et al. 2018. "Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles" Pharmaceutics 10, no. 4: 277. https://doi.org/10.3390/pharmaceutics10040277

APA Style

Briguglio, M., Hrelia, S., Malaguti, M., Serpe, L., Canaparo, R., Dell’Osso, B., Galentino, R., De Michele, S., Zanaboni Dina, C., Porta, M., & Banfi, G. (2018). Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles. Pharmaceutics, 10(4), 277. https://doi.org/10.3390/pharmaceutics10040277

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