Next Article in Journal
Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization and Drug Nanoencapsulation
Next Article in Special Issue
Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films
Previous Article in Journal
Investigations Concerning the Residence Time Distribution of Twin-Screw-Extrusion Processes as Indicator for Inherent Mixing
Previous Article in Special Issue
Molecular Disorder of Bicalutamide—Amorphous Solid Dispersions Obtained by Solvent Methods
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceutics
Volume 10
Issue 4
10.3390/pharmaceutics10040208
pharmaceutics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Development and Evaluation of a Water Soluble Fluorometholone Eye Drop Formulation Employing Polymeric Micelle

by
Gyubin Noh
1,
Taekwang Keum
1,
Jo-Eun Seo
1,
Jaewoong Choi
1,
Bastola Rakesh
1,
Lamichhane Shrawani
1,
Byoungduck Park
1,
Young Wook Choi
2 and
Sangkil Lee
1,*
1
College of Pharmacy, Keimyung University, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Korea
2
College of Pharmacy, Chung-Ang University, 221 Heuksuk-dong, Dongjak-gu, Seoul 06974, Korea
*
Author to whom correspondence should be addressed.
Pharmaceutics 2018, 10(4), 208; https://doi.org/10.3390/pharmaceutics10040208
Submission received: 28 September 2018 / Revised: 22 October 2018 / Accepted: 26 October 2018 / Published: 28 October 2018
(This article belongs to the Special Issue New Approaches to Enhance Drug Solubility and Bioavailability)
Browse Figures
Versions Notes

Abstract

Low aqueous solubility of drug causes difficulties in preparation and inconvenience of administration. Polymeric micelles of fluorometholone (FML) using solid dispersion technique were prepared to develop an eye drop formulation with enhanced water solubility. Solid dispersions of FML were prepared at various FML:Soluplus® w/w ratios using solvent evaporation method. A physical mixture was also prepared. Physicochemical characterization was performed with various methods. Ex vivo porcine corneal permeation of polymeric micelle, physical mixture, and commercial product were compared. FML solid dispersion (1:15) showed the highest solubility, which was c.a. 169.6- and 15.3-fold higher than that of pure FML and physical mixture. Characterization showed that the crystalline form of FML changed to amorphous state and polymeric micelles were formed in round micelle. Flucon®, a commercial product of FML, showed significantly large particle size and high poly dispersity index. In contrast, FML polymeric micelle showed submicron size with uniform size distribution. Ex vivo porcine corneal permeation study showed that permeation by polymeric micelles was significantly higher than that by the commercial product and physical mixture. In addition, confocal laser scanning microscopic analysis supported the enhanced porcine corneal tissue permeation property of polymeric micelle. In conclusion, polymeric micelle prepared with solid dispersion using Soluplus® can be a potential nanomedicine for ocular delivery of poorly water-soluble FML.
Keywords: Soluplus®; fluorometholone; polymeric micelle; solid dispersion; nanomedicine; ocular drug delivery Soluplus®; fluorometholone; polymeric micelle; solid dispersion; nanomedicine; ocular drug delivery
Graphical Abstract

Share and Cite

MDPI and ACS Style

Noh, G.; Keum, T.; Seo, J.-E.; Choi, J.; Rakesh, B.; Shrawani, L.; Park, B.; Choi, Y.W.; Lee, S. Development and Evaluation of a Water Soluble Fluorometholone Eye Drop Formulation Employing Polymeric Micelle. Pharmaceutics 2018, 10, 208. https://doi.org/10.3390/pharmaceutics10040208

AMA Style

Noh G, Keum T, Seo J-E, Choi J, Rakesh B, Shrawani L, Park B, Choi YW, Lee S. Development and Evaluation of a Water Soluble Fluorometholone Eye Drop Formulation Employing Polymeric Micelle. Pharmaceutics. 2018; 10(4):208. https://doi.org/10.3390/pharmaceutics10040208

Chicago/Turabian Style

Noh, Gyubin, Taekwang Keum, Jo-Eun Seo, Jaewoong Choi, Bastola Rakesh, Lamichhane Shrawani, Byoungduck Park, Young Wook Choi, and Sangkil Lee. 2018. "Development and Evaluation of a Water Soluble Fluorometholone Eye Drop Formulation Employing Polymeric Micelle" Pharmaceutics 10, no. 4: 208. https://doi.org/10.3390/pharmaceutics10040208

APA Style

Noh, G., Keum, T., Seo, J.-E., Choi, J., Rakesh, B., Shrawani, L., Park, B., Choi, Y. W., & Lee, S. (2018). Development and Evaluation of a Water Soluble Fluorometholone Eye Drop Formulation Employing Polymeric Micelle. Pharmaceutics, 10(4), 208. https://doi.org/10.3390/pharmaceutics10040208

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop