Keratinocyte Differentiation-Dependent Human Papillomavirus Gene Regulation
Abstract
:1. Introduction
2. Viral Genome Organization
2.1. Early Gene Expression
2.2. Late Gene Expression and the Late Promoter
3. Viral Late Promoter Activity
4. Differentiation-Dependent Regulation of Polyadenylation
4.1. Repression of the Early Polyadenylation Site and Late Gene Expression
4.2. Control of Late Gene Expression Occurs at Multiple Post-Transcriptional Levels
4.3. Control of Late Polyadenylation
4.4. Regulation of Late RNA Stability
4.5. Late RNA Splicing
4.6. Control of Late mRNA Splicing
4.7. Control of Capsid Protein Translation
5. Conclusions
Acknowledgments
Conflicts of Interest
References
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HPV Genotype | Protein | Function |
---|---|---|
HPV1 | HuR | mRNA stability, polyadenylation, nuclear export |
hnRNPC1/C2 | Splicing, polyadenylation, mRNA stability, nuclear export | |
PABP | Polyadenylation, translation | |
HPV16 | U1snRNP | splicing |
HuR 1 | mRNA stability, polyadenylation, nuclear export | |
SRSF1 3 | Splicing regulation | |
hnRNP A1 | Splicing regulation | |
U2AF | Auxiliary splicing factor | |
CstF-64 | Polyadenylation | |
CUG-BP | Alternative splicing, translation | |
HPV31 | U1snRNP 2 | splicing |
HuR | mRNA stability, polyadenylation, nuclear export | |
U2AF | Auxiliary splicing factor | |
CstF-64 | Polyadenylation | |
HPV18 | U1snRNP2 | splicing |
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Graham, S.V. Keratinocyte Differentiation-Dependent Human Papillomavirus Gene Regulation. Viruses 2017, 9, 245. https://doi.org/10.3390/v9090245
Graham SV. Keratinocyte Differentiation-Dependent Human Papillomavirus Gene Regulation. Viruses. 2017; 9(9):245. https://doi.org/10.3390/v9090245
Chicago/Turabian StyleGraham, Sheila V. 2017. "Keratinocyte Differentiation-Dependent Human Papillomavirus Gene Regulation" Viruses 9, no. 9: 245. https://doi.org/10.3390/v9090245