Next Article in Journal
RNA Virus Evolution via a Quasispecies-Based Model Reveals a Drug Target with a High Barrier to Resistance
Next Article in Special Issue
The Influence of E1A C-Terminus on Adenovirus Replicative Cycle
Previous Article in Journal
Characterization of Ovine A3Z1 Restriction Properties against Small Ruminant Lentiviruses (SRLVs)
Previous Article in Special Issue
PERK Signal-Modulated Protein Translation Promotes the Survivability of Dengue 2 Virus-Infected Mosquito Cells and Extends Viral Replication

Epigenetic Regulation of Viral Biological Processes

Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
Author to whom correspondence should be addressed.
Viruses 2017, 9(11), 346;
Received: 31 October 2017 / Revised: 13 November 2017 / Accepted: 15 November 2017 / Published: 17 November 2017
(This article belongs to the Special Issue Viral Subversion of Transcriptional Control)
It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. This review will address epigenetic regulation in members of the polyomaviruses, adenoviruses, human papillomaviruses, hepatitis B, and herpes viruses. For each type of virus, what is known about the roles of DNA methylation, histone modifications, nucleosome positioning, and regulatory RNA in epigenetic regulation of the virus infection will be discussed. The mechanisms used by certain viruses to dysregulate the host cell through manipulation of epigenetic processes and the role of cellular cofactors such as BRD4 that are known to be involved in epigenetic regulation of host cell pathways will also be covered. Specifically, this review will focus on the role of epigenetic regulation in maintaining viral episomes through the generation of chromatin, temporally controlling transcription from viral genes during the course of an infection, regulating latency and the switch to a lytic infection, and global dysregulation of cellular function. View Full-Text
Keywords: epigenetic; DNA virus; regulation; gene expression; histone modifications; nucleosomes; DNA methylation; ChIP-Seq; latency epigenetic; DNA virus; regulation; gene expression; histone modifications; nucleosomes; DNA methylation; ChIP-Seq; latency
Show Figures

Graphical abstract

MDPI and ACS Style

Balakrishnan, L.; Milavetz, B. Epigenetic Regulation of Viral Biological Processes. Viruses 2017, 9, 346.

AMA Style

Balakrishnan L, Milavetz B. Epigenetic Regulation of Viral Biological Processes. Viruses. 2017; 9(11):346.

Chicago/Turabian Style

Balakrishnan, Lata; Milavetz, Barry. 2017. "Epigenetic Regulation of Viral Biological Processes" Viruses 9, no. 11: 346.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop